36725-27-6

Basic information

• Product Name: Acetamide, N-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-
• Synonyms: 5-methyl-6-(4-acetamidophenyl)-4,5-dihydro-3(2H)-pyridazinone;[4-(tetrahydro-4-methyl-6-oxo-3-pyridazinyl)-phenyl]-acetamide;SKF 93741;6-(4-acetylamino-phenyl)-5-methyl-4,5-dihydro-2H-pyridazin-3-one;6-(p-Acetamidophenyl)-4,5-dihydro-5-methyl-3-(2H)pyridazinon
• CAS NO: 36725-27-6
• Molecular Formula: C13H15N3O2
• Molecular Weight: 245.281
• Mol File: 36725-27-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Acetamide, N-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-(36725-27-6)
• EPA Substance Registry System: Acetamide, N-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-(36725-27-6)

Safety Data

• Hazardous Substances Data: 36725-27-6(Hazardous Substances Data)

Upstream product

• 5473-15-4 4-(4-acetamidophenyl)-4-oxobutanoic acid 
• 120757-15-5 4-(4-Amino-phenyl)-4-oxo-3-piperidin-1-ylmethyl-butyric acid methyl ester 
• 120757-14-4 3-(4-acetamidobenzoyl)-4-(N-piperidinyl)butanoic acid 
• 120757-16-6 3-(4-Acetylamino-benzoyl)-but-3-enoic acid methyl ester 
• 120757-17-7 methyl 3-(4-acetaminobenzoyl)butyrate 

Downstream Products

• 36725-28-7 6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone 
• 52240-11-6 6-(4-aminophenyl)-5-methylpyridazine-3(2H)-one 
• 115344-47-3 2 cyano 1 methyl 3 [4 (4 methyl 6 oxo 1,4,5,6 tetrahydro 3 pyridazinyl)phenyl]guanidine 
• 99591-85-2 6-<4-(N'-cyano-S-methylisothioureido)phenyl>-5-methyl-4,5-dihydropyridazin-3(2H)-one 

Relevant articles and documents

6-(substituted phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-ones of medicinal interest. The synthesis of SK&F 94836 and SK&F 95654

Two synthetic routes to the dihydropyridazinone-cyanoguanidine 4 (SK&F 94836) are described, both proceeding via the anilino compound 6. An efficient synthesis of the dihydropyridazinone-pyridone 5 (SK&F 95654) is reported. This synthesis proceeds via the fluoro-keto-acid 24, with subsequent displacement of the fluoro substituent by 4-pyridone. The surprising effectiveness of water as a solvent in this reaction has been highlighted.

6 Phenyl 4,5 dihydro 3(2H) pyridazinones. A series of hypotensive agents

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