1208231-02-0Relevant articles and documents
Solution-phase microwave assisted parallel synthesis, biological evaluation and in silico docking studies of 2-chlorobenzoyl thioureas derivatives
Khan, Muhammad Riaz,Zaib, Sumera,Rauf, Muhammad Khawar,Ebihara, Masahiro,Badshah, Amin,Zahid, Muhammad,Nadeem, Muhammad Arif,Iqbal, Jamshed
, p. 354 - 362 (2018/05/29)
An efficient and facile microwave-assisted solution phase parallel synthesis for a 38-member library of N-aroyl-N′-aryl thioureas was accomplished successfully. These analogues (1–38) were synthesized under identical set of conditions. It has been observe
Synthesis and antimicrobial activity of some novel 2-(substituted fluorobenzoylimino)-3-(substituted fluorophenyl)-4-methyl-1,3-thiazolines
Saeed, Aamer,Shaheen, Uzma,Hameed, Abdul,Kazmi, Faiza
body text, p. 333 - 339 (2010/04/30)
The synthesis of several 2-(substituted fluorobenzoylimino)-3-(substituted fluorophenyl)-4-methyl-1,3-thiazolines (2a-t) was carried out by base-catalyzed cyclization of corresponding 1-(fluorobenzoyl)-3-(fluorophenyl)thioureas (1a-t) with 2-bromoacetone in aqueous medium. The structures of the synthesized compounds were confirmed by spectral and elemental analysis. All synthesized compounds were evaluated for in vitro antibacterial activity using Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis) and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa). The minimum inhibitory concentration (MIC) was determined for the most active compounds. In vitro antifungal activity was also determined against the five fungal species (Rhizopus oryzae, Fusarium oxysporum, Aspergillus terreus, A. niger and A. fumigatus).