91121-61-8Relevant academic research and scientific papers
Electrochemical synthesis of α-hydroxycarboxylic acids from acetophenones
Khaja Lateef,Ramesh Raju,Krishna Mohan,Jayarama Reddy
, p. 31 - 36 (2007/10/03)
α-Hydroxy carboxylic acids are synthesized in 80-86% isolated yields by electrochemical carboxylation of methyl aryl ketones in the presence of carbon dioxide (1 atm.) using a platinum cathode and a sacrificial magnesium anode at a constant current density of 10 mA/cm2. Reversibility of the carbonyl group reduction and generation of anionic radical were shown by cyclic voltammetry. Copyright Taylor & Francis LLC.
Benzopyran derivatives
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, (2008/06/13)
PCT No. PCT/KR97/00265 Sec. 371 Date Jun. 8, 1999 Sec. 102(e) Date Jun. 8, 1999 PCT Filed Dec. 13, 1997 PCT Pub. No. WO98/25916 PCT Pub. Date Jun. 18, 1998The present invention relates to a novel benzopyran derivative having anti-estrogenic activity. More
Chemoenzymatic synthesis of pure enantiomeric 2-aryl propionic acids
Garcia,Del Campo,Llama,Sanchez-Montero,Sinisterra
, p. 8433 - 8440 (2007/10/02)
A new chemoenzymatic procedure to obtain pure enantiomeric 2-arylpropionic acids is described. The one pot synthesis of (±)-2-arylpropionic acids is carried out by addition of dichlorocarbene to the C=O bond of arylmethylketones and hydrogenolysis of the additon product. The racemic mixture is resolved by enantiospecific hydrolysis of the racemic ethyl esters using native lipase from Candida rugosa. The good yields, the accessibility of the starting arylmethylketones and the stereospecificity of the enzymatic hydrolysis make the process interesting in order to obtain the same non steroidal antiinflammatory drugs such as Ibuprofen or Naproxen.
