121-18-6

Usage

Uses

Used in Organic Synthesis:
4-Chloro-3-nitrobenzenesulfonic acid is utilized as a reagent in organic synthesis for its ability to participate in a range of chemical reactions, facilitating the creation of diverse organic compounds.
Used in Pharmaceutical Preparation:
As a precursor, 4-Chloro-3-nitrobenzenesulfonic acid is instrumental in the preparation of various pharmaceuticals. Its unique structure allows it to be a key component in the synthesis of drug molecules.
Used in Dye Production:
4-Chloro-3-nitrobenzenesulfonic acid also finds application in the production of dyes, where its chemical properties contribute to the color and stability of the final product.
Used in Chemical Research:
4-Chloro-3-nitrobenzenesulfonic acid is employed in chemical research for studying reaction mechanisms and exploring new synthetic pathways, given its reactivity and functional groups.
It is crucial to handle 4-Chloro-3-nitrobenzenesulfonic acid with care due to its corrosive nature and potential toxicity, ensuring safety in its applications across different industries.

InChI:InChI=1/C6H4ClNO5S/c7-5-2-1-4(14(11,12)13)3-6(5)8(9)10/h1-3H,(H,11,12,13)

Upstream product

• 98-66-8 4-chloro-benzenesulfonic acid 
• 88-73-3 2-Chloronitrobenzene 
• 108-90-7 chlorobenzene 
• 7664-93-9 sulfuric acid 
• 1142-19-4 4,4'-dichlorodiphenyl disulfide 
• 7697-37-2 nitric acid 
• 97-08-5 3-nitro-4-chlorosulfonyl chloride 
• 98-64-6 4-Chlorobenzenesulfonamide 

Downstream Products

• 119-00-6 2-nitro-1,4-benzenedisulfonic acid 
• 98-37-3 2-aminophenol-4-sulfonic acid 
• 120-82-1 1,2,4-Trichlorobenzene 
• 42293-31-2 3-amino-4-o-tolyloxy-benzenesulfonic acid 
• 127204-95-9 4-chloro-5-nitro-2-cyanomethylbenzenesulfonic acid 
• 127204-94-8 4-chloro-5-nitro-2-phenylsulfonylmethylbenzenesulfonic acid 
• 616-84-2 2-nitroaniline-4-sulfonic acid 
• 97-09-6 4-Chloro-3-nitrobenzenesulfonamide 
• 118266-09-4 2-Nitro-4'-N,N-bis(2-hydroxyethyl)-aminodiphenylamine-4-sulfonic acid, sodium salt 
• 128646-71-9 4-amino-2'-nitro-4'-sulfodiphenyl sulfone 
• 1270171-46-4 4-[N-(3'-aminopropyl)-2-pyrrolidone]-3-nitrobenzenesulfonic acid 
• 1270171-48-6 4-[N-(3'-aminopropyl)-2-azepanone]-3-nitrobenzenesulfonic acid 
• 50667-33-9 4-amino-3-nitrobenzenesulfonic acid ammonium 
• 3970-37-4 1-bromo-2-chloro-3-nitrobenzene 

Relevant academic research and scientific papers

Sulfonation method of aromatic hydrocarbons with low electron cloud density

The invention discloses a sulfonation method of aromatic hydrocarbons with a low electron cloud density. The sulfonation method comprises following steps: (1) in a solvent, taking metal sulfate as a catalyst, mixing chlorosulfonic acid and an aromatic hydrocarbon substrate according to a mole ratio of 1.2-1.5:1, and carrying out sulfonation reactions for 1 to 5 hours, wherein the aromatic hydrocarbon substrate is aromatic hydrocarbons with a low electron cloud density and the solvent is an inert reagent; and (2) subjecting the reaction product obtained in the step (1) to reduced pressure distillation to remove the solvent, after reduced pressure distillation, pouring residues into ice water, adjusting the pH to 0.9-1.1, filtering, and drying the filter cakes to obtain a sulfonation product. The provided sulfonation method has a high yield and reduces the discharge of waste acids.

Synthesis and antistaphylococcal activity of N-substituted-1H- benzimidazole-sulphonamides

A series of N-substituted-1H-benzimidazole-5(6)-sulfonamides and 3-(5,6-dichloro-1H-benzimidazol-2-yl)-N-substituted benzensulfonamides were synthesized and evaluated for antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA). Certain compounds inhibit bacterial growth with low MIC (μg/mL) values. The most active compounds 30, 31, and 32 have the lowest MIC values with 0.39 to 0.19 μg/mL. Among the compounds having sulfonamido moities, 16, 23, and 24 exhibited the strongest antibacterial activity with 1.56 μg/mL MIC values.