121-18-6

Basic information

• Product Name: 4-Chloro-3-nitrobenzenesulfonic acid
• Synonyms: 4-CHLORO-3-NITROBENZENESULFONIC ACID;2-NITRO-1-CHLOROBENZENE-4-SULFONIC ACID;4-chloro-3-nitrobenzenesulphonic acid;o-Nitrochlorobenzene-p-sulfonic acid;3-Nitro-4-chlorobenzenesulfonic acid;4-Chloro-5-nitrobenzenesulfonic acid;Benzenesulfonicacid,4-chloro-3-nitro-;4-chloro-3-nitro-benzenesulfonicaci
• CAS NO: 121-18-6
• Molecular Formula: C₆H₄ClNO₅S
• Molecular Weight: 237.62
• EINECS: 204-452-1
• Product Categories: Intermediates of Dyes and Pigments
• Mol File: 121-18-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 114-115 °C
• Appearance: /
• Density: 1.747 g/cm³
• Refractive Index: 1.623
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -1.44±0.50(Predicted)
• CAS DataBase Reference: 4-Chloro-3-nitrobenzenesulfonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-3-nitrobenzenesulfonic acid(121-18-6)
• EPA Substance Registry System: 4-Chloro-3-nitrobenzenesulfonic acid(121-18-6)

Safety Data

• Hazardous Substances Data: 121-18-6(Hazardous Substances Data)

Usage

General Description

4-Chloro-3-nitrobenzenesulfonic acid, also known as 4-chloro-3-nitrobenzenesulfonate, is a chemical compound with the molecular formula C6H4ClNO5S. It is an aromatic organic compound that contains a chlorine atom, a nitro group, and a sulfonic acid group attached to a benzene ring. 4-Chloro-3-nitrobenzenesulfonic acid is commonly used as a reagent in organic synthesis and as a precursor for the preparation of various pharmaceuticals and dyes. It is a yellow solid at room temperature and is highly soluble in water. It is important to handle 4-Chloro-3-nitrobenzenesulfonic acid with caution as it is a corrosive and potentially toxic substance.

InChI:InChI=1/C6H4ClNO5S/c7-5-2-1-4(14(11,12)13)3-6(5)8(9)10/h1-3H,(H,11,12,13)

Upstream product

• 98-66-8 4-chloro-benzenesulfonic acid 
• 108-90-7 chlorobenzene 
• 7664-93-9 sulfuric acid 
• 88-73-3 2-Chloronitrobenzene 
• 1142-19-4 4,4'-dichlorodiphenyl disulfide 
• 7697-37-2 nitric acid 
• 97-08-5 3-nitro-4-chlorosulfonyl chloride 
• 98-64-6 4-Chlorobenzenesulfonamide 

Downstream Products

• 42293-31-2 3-amino-4-o-tolyloxy-benzenesulfonic acid 
• 98-37-3 2-aminophenol-4-sulfonic acid 
• 120-82-1 1,2,4-Trichlorobenzene 
• 3970-37-4 1-bromo-2-chloro-3-nitrobenzene 
• 50667-33-9 4-amino-3-nitrobenzenesulfonic acid ammonium 
• 1270171-48-6 4-[N-(3'-aminopropyl)-2-azepanone]-3-nitrobenzenesulfonic acid 
• 1270171-46-4 4-[N-(3'-aminopropyl)-2-pyrrolidone]-3-nitrobenzenesulfonic acid 
• 119-00-6 2-nitro-1,4-benzenedisulfonic acid 
• 128646-71-9 4-amino-2'-nitro-4'-sulfodiphenyl sulfone 
• 532-02-5 2-naphthalenesulfonic acid sodium salt 
• 118266-09-4 2-Nitro-4'-N,N-bis(2-hydroxyethyl)-aminodiphenylamine-4-sulfonic acid, sodium salt 
• 97-09-6 4-Chloro-3-nitrobenzenesulfonamide 
• 6421-84-7 5-(2-amino-4-sulfo-benzenesulfonyl)-2-hydroxy-benzoic acid 

Relevant articles and documents

Sulfonation method of aromatic hydrocarbons with low electron cloud density

The invention discloses a sulfonation method of aromatic hydrocarbons with a low electron cloud density. The sulfonation method comprises following steps: (1) in a solvent, taking metal sulfate as a catalyst, mixing chlorosulfonic acid and an aromatic hydrocarbon substrate according to a mole ratio of 1.2-1.5:1, and carrying out sulfonation reactions for 1 to 5 hours, wherein the aromatic hydrocarbon substrate is aromatic hydrocarbons with a low electron cloud density and the solvent is an inert reagent; and (2) subjecting the reaction product obtained in the step (1) to reduced pressure distillation to remove the solvent, after reduced pressure distillation, pouring residues into ice water, adjusting the pH to 0.9-1.1, filtering, and drying the filter cakes to obtain a sulfonation product. The provided sulfonation method has a high yield and reduces the discharge of waste acids.

SULFONATION OF o- AND p-NITROCHLOROBENZENES BY HIGH-PERCENTAGE OLEUM

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