129643-72-7

Upstream product

• 2476-37-1 2,5-dichloroacetophenone 
• 1193-00-6 sodium 4-chlorophenolate 
• 5780-37-0 (E)-acetaldoxime 
• 121-27-7 2-(4'-chlorophenoxy)-5-chloro-aniline 
• 7758-99-8 copper(II) sulfate 
• 7757-82-6 sodium sulfate 

Downstream Products

• 57388-57-5 2-(4-chloro-phenoxy)-5-chloro-phenylacetic acid 
• 3380-53-8 Acetic acid 5-chloro-2-(4-chloro-phenoxy)-phenyl ester 

Relevant academic research and scientific papers

Process for the preparation of halogenated hydroxydiphenyl compounds

A process for the preparation of halohydroxydiphenyl compounds useful for protecting organic materials and articles from microorganisms, of the formula by acylation of a halogenated benzene compound (first stage), etherification of the acylated compound with a halogenated phenol compound (second stage), oxidation of the etherified compound (third stage) and hydrolysis of the oxidized compound in a fourth stage, according to the following reaction scheme: in which R1 and R2 independently of one another are F, Cl or Br; R3 and R4 independently of one another are hydrogen; or C1-C4alkyl; m is 1 to 3; and n is 1 or 2.

Antimycotically active substituted 2-aminothiazoles

A 2-aminothiazole of the formula STR1 in which R1 represents hydrogen or alkyl and R2 represents a radical of the formula STR2 where R3, R4, R5 and R6 independently of one another in each case represent hydrogen, halogen, nitro, alkyl, alkoxy, alkoxycarbonyl, dialkylamino, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, halogenoalkylsulphinyl or halogenoalkylsulphonyl, X represents oxygen, sulphur, sulphinyl or sulphonyl and Ar represents an unsubstituted aryl or a substituted aryl radical, and their physiologically tolerable acid addition salts.

Substituted (2-Phenoxyphenyl)acetic Acids with Antiinflammatory Activity. 1

The synthesis and antiinflammatory activity of a series of substituted (2-phenoxyphenyl)acetic acids are described.Initial screening in the adjuvant arthritis test showed that halogen substitution in the phenoxy ring enhanced activity considerably.Ulcerogenic potential, as measured by the minimum ulcerogenic dose (MUD), was low in almost all the acids tested. acetic acid possessed the most favorable combination of potency with low toxicity, including ulcerogenicity, and this compound is now in therapeutic use.