121089-86-9Relevant academic research and scientific papers
Synthesis and contractile activity of substituted 1,2,3,4- tetrahydroisoquinolines
Ivanov, Iliyan,Nikolova, Stoyanka,Aladjov, Dimo,Stefanova, Iliyana,Zagorchev, Plamen
experimental part, p. 7019 - 7042 (2011/11/05)
A series of different 1-monosubstituted and 1,1-disubstituted 1,2,3,4-tetrahydroisoquinolines was synthesized in high yields from different ketoamides. We have developed a convenient method for the synthesis of disubstituted derivatives by interaction of
Application of the ortho-Lithiation-Cyclization Strategy to N-Benzyl- and N-Phenethylamine Derivatives
Lete, Esther,Collado, M. Isabel,Sotomayor, Nuria,Vicente, Teresa,Villa, Maria-Jesus
, p. 1751 - 1758 (2007/10/03)
The ortho-lithiation-cyclization of iodinated N,N-diacylphenethylamines provides a convenient method for the preparation of 2-(2-acetoamidoethyl)acetophenones and 2-(2-benzamidoethyl)benzophenones, which could be easily transformed into dihydroisoquinolines.By contrast, the N-ethylamino, N-acetylamino, and N-trimethylsilylamino moieties studied as ortho-directing groups provide poor assistance to the metalation of N-benzyl- and N-phenyethylamines and the corresponding isoindolone or isoquinolone derivatives are obtained in low yields.
STUDIES ON FRIEDEL-CRAFTS ACYLATION OF N-ACETYLHOMOVERATRYLAMINE AND PREPARATION OF 1-SUBSTITUTED 3,4-DIHYDRO-6,7-DIMETHOXYISOQUINOLINES
Orito, Kazuhiko,Matsuzaki, Tsutomu,Suginome, Hiroshi,Rodrigo, Russel
, p. 2403 - 2412 (2007/10/02)
Friedel-Crafts acylation of N-acetylhomoveratrylamine in a molar ratio of 1:2:3 of 1, AlCl3 and the appropriate acid chloride using nitrobenzene as solvent gave the corresponding 2-acyl derivatives 2a-j in good yields.Subsequent treatment of 2 in boiling
