174533-47-2

Upstream product

• 66384-45-0 N-acetyl-2-iodo-4,5-dimethoxy-β-phenethylamine 
• 98-88-4 benzoyl chloride 
• 6275-29-2 N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 174533-44-9 N,N-dibenzoyl-N-2-(3,4-dimethoxyphenyl)ethylamine 

Downstream Products

• 32438-32-7 N-(2-acetyl-4,5-dimethoxyphenethyl)benzamide 
• 121089-86-9 N-(2-benzoyl-4,5-dimethoxyphenethyl)acetamide 

Relevant academic research and scientific papers

Application of the ortho-Lithiation-Cyclization Strategy to N-Benzyl- and N-Phenethylamine Derivatives

The ortho-lithiation-cyclization of iodinated N,N-diacylphenethylamines provides a convenient method for the preparation of 2-(2-acetoamidoethyl)acetophenones and 2-(2-benzamidoethyl)benzophenones, which could be easily transformed into dihydroisoquinolines.By contrast, the N-ethylamino, N-acetylamino, and N-trimethylsilylamino moieties studied as ortho-directing groups provide poor assistance to the metalation of N-benzyl- and N-phenyethylamines and the corresponding isoindolone or isoquinolone derivatives are obtained in low yields.