1211586-75-2

Upstream product

• 75-89-8 2,2,2-trifluoroethanol 
• 29241-62-1 5-bromo-6-chloronicotinic acid 

Downstream Products

• 1269826-52-9 5-Bromo-N-((1S,2R)-2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide 
• 1364678-33-0 5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid 
• 1427064-19-4 5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid hydrazide 
• 1427064-68-3 5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid methyl ester 
• 1364678-31-8 5-(3-chloro-4-fluorophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid 
• 1269826-45-0 5-(3,4-dichloro-phenyl)-N-((1 S,2R)-2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide 
• 1269826-44-9 5-(3,4-dichlorophenyl)-N-((1R,2R)-2-hydroxycyclohexyl)-6-(2,2,2-trifluoroethoxy)nicotinamide 
• 1269826-46-1 5-Bromo-N-((1R,2R)-2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide 

Relevant academic research and scientific papers

5- (3, 4-DICHLORO-PHENYL) -N- (2-HYDROXY-CYCLOHEXYL) -6- (2,2, 2-TRIFLUORO-ETHOXY) -NICO TINAMIDE AND SALTS THEREOF AS HDL CHOLESTEROL RAISING AGENTS

The present invention relates to a compound of the formula in all its isomeric forms and pharmaceutically acceptable salts thereof, their manufacture, pharmaceutical compositions containing them and their use as medicaments for the treatment and/or prophylaxis of diseases which can be treated with HDL-cholesterol raising agents, such as preferably dyslipidemia, atherosclerosis and cardiovascular diseases.

5-(3,4-DICHLORO-PHENYL)-N-(2-HYDROXY-CYCLOHEXYL)-6-(2,2,2-TRIFLUORO-ETHOXY)-NICOTINAMIDE AND SALTS THEREOF

The present invention relates to a compound of formula I, in all its isomeric forms and pharmaceutically acceptable salts thereof, their manufacture, pharmaceutical compositions containing them and their use as medicaments for the treatment and/or prophylaxis of diseases which can be treated with HDL-cholesterol raising agents, such as dyslipidemia, atherosclerosis and cardiovascular diseases.