121195-01-5

Upstream product

• 100-39-0 benzyl bromide 
• 118464-50-9 6-O-tert-butyldimethylsilyl-2,3-O-isopropylidene-D-mannono-δ-lactam 
• 121194-93-2 N-benzyl-4-O-benzyl-6-O-tert-butyldimethylsilyl-2,3-O-isopropylidene-D-mannono-δ-lactam 
• 118493-81-5 (3aR,6R,7R,7aS)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-hexahydro-[1,3]dioxolo[4,5-c]pyridin-7-ol 
• 1826-67-1 vinyl magnesium bromide 
• 121194-99-8 (3aR,6S,7R,7aR)-5-Benzyl-7-benzyloxy-2,2-dimethyl-hexahydro-[1,3]dioxolo[4,5-c]pyridine-6-carbaldehyde 
• 118493-82-6 6-O-tert-butyldimethylsilyl-2,3-O-isopropylidene-L-mannono-δ-lactam 
• 121194-99-8 (3aS,6R,7S,7aS)-5-Benzyl-7-benzyloxy-2,2-dimethyl-hexahydro-[1,3]dioxolo[4,5-c]pyridine-6-carbaldehyde 
• 121194-96-5 N-benzyl-4-O-benzyl-1,5-dideoxy-1,5-imino-2,3-O-isopropylidene-D-mannitol 
• 121250-65-5 N-benzyl-4-O-benzyl-6-O-tert-butyldimethylsilyl-2,3-O-isopropylidene-L-mannono-δ-lactam 
• 121251-74-9 N-benzyl-4-O-benzyl-1,5-dideoxy-1,5-imino-2,3-O-isopropylidene-L-mannitol 

Downstream Products

• 121251-77-2 N-benzyl-4-O-benzyl-6-O-tert-butyldimethylsilyl-1,5,7-trideoxy-1,5-imino-2,3-O-isopropylidene-L-glycero-L-manno-octitol 
• 121251-78-3 N-benzyl-4-O-benzyl-6-O-tert-butyldimethylsilyl-1,5,7-trideoxy-1,5-imino-2,3-O-isopropylidene-D-glycero-L-manno-octitol 
• 121195-00-4 N-benzyl-4-O-benzyl-6-O-tert-butyldimethylsilyl-1,5,7,8-tetradeoxy-1,5-imino-2,3-O-isopropylidene-DL-glycero-L-manno-oct-7-enitol 
• 121195-00-4 (3aS,6R,7S,7aS)-5-Benzyl-7-benzyloxy-6-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-allyl]-2,2-dimethyl-hexahydro-[1,3]dioxolo[4,5-c]pyridine 
• 121251-76-1 (3aS,6R,7S,7aS)-5-Benzyl-7-benzyloxy-6-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-allyl]-2,2-dimethyl-hexahydro-[1,3]dioxolo[4,5-c]pyridine 
• 117894-11-8 L-6-epicastanospermine 
• 117894-10-7 L-1,6-diepicastanospermine 
• 121194-94-3 (3aS,8R,8aR,9S,9aS)-5-Benzyl-9-benzyloxy-8-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-octahydro-[1,3]dioxolo[4,5-f]indolizin-5-ium 
• 131898-23-2 (3aS,8S,8aR,9S,9aS)-5-Benzyl-9-benzyloxy-8-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-octahydro-[1,3]dioxolo[4,5-f]indolizin-5-ium 
• 121194-98-7 (3aS,8R,8aR,9S,9aS)-9-Benzyloxy-8-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-octahydro-[1,3]dioxolo[4,5-f]indolizine 
• 121194-98-7 (3aS,8S,8aR,9S,9aS)-9-Benzyloxy-8-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-octahydro-[1,3]dioxolo[4,5-f]indolizine 
• 121194-95-4 N-benzyl-4-O-benzyl-6-O-tert-butyldimethylsilyl-2,3-O-isopropylidene-(1S,6S,7S,8S,8aS)-1,6,7,8-tetrahydroxyoctahydroindolizinium methanesulphonate 
• 131898-24-3 N-benzyl-4-O-benzyl-6-O-tert-butyldimethylsilyl-2,3-O-isopropylidene-(1R,6S,7S,8S,8aS)-1,6,7,8-tetrahydroxyoctahydroindolizinium methanesulphonate 
• 121195-00-4 N-benzyl-4-O-benzyl-6-O-tert-butyldimethylsilyl-1,5,7,8-tetradeoxy-1,5-imino-2,3-O-isopropylidene-DL-glycero-D-manno-oct-7-enitol 

Relevant academic research and scientific papers

Synthesis of the enantiomers of 6-epicastanospermine and 1,6-diepicastanospermine from D- and L-gulonolactone.

The synthesis of the enantiomers of 6-epicastanospermine and of 1,6-diepicastanospermine from the enantiomeric gulonolactones is reported and the structure of the former is established as (1S,6R,7R,8R,8aR)-1,6,7,8-tetrahydroxyoctahydroindolizine. The inhibitory activities of the diastereomers against the amyloglucosidase-catalysed hydrolysis of p-nitrophenyl alpha-D-glucopyranoside were investigated, and the effects of 6-epicastanospermine and of 1,6-diepicastanospermine on 14 human liver glycosidases are reported.

SYNTHESIS OF 6-EPICASTANOSPERMINE AND 1,6-DIEPICASTANOSPERMINE FROM L-GULONOLACTONE AND SYNTHESIS OF L-6-EPICASTANOSPERMINE AND L-1,6-DIEPICASTANOSPERMINE FROM D-GULONOLACTONE.

The syntheses of the natural product 6-epicastanospermine , isolated from Castanospermum australe, and of 1,6-diepicastanospermine -1,6,7,8-tetrahydroxyoctahydroindolizine> from