1212409-03-4

Usage

Uses

Used in Organic Synthesis:
(3S,4S)-pyrrolidine-1,3,4-tricarboxylic acid 1-tert-butyl ester 3-ethyl ester serves as a versatile intermediate in organic synthesis, particularly for the creation of complex molecules and pharmaceutical agents. Its unique structure and functional groups make it a valuable building block for developing new compounds with specific properties.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (3S,4S)-pyrrolidine-1,3,4-tricarboxylic acid 1-tert-butyl ester 3-ethyl ester may be utilized as a precursor for the synthesis of potential drug candidates. Its ability to form various derivatives due to the presence of multiple carboxylic acid and ester groups can be exploited to design molecules with specific biological activities.
Used as a Reference Standard in Analytical Chemistry:
(3S,4S)-pyrrolidine-1,3,4-tricarboxylic acid 1-tert-butyl ester 3-ethyl ester can also be employed as a reference standard for analytical purposes. Its defined stereochemistry and structural features make it suitable for calibrating instruments and validating analytical methods in quality control and research laboratories.
The specific applications and properties of (3S,4S)-pyrrolidine-1,3,4-tricarboxylic acid 1-tert-butyl ester 3-ethyl ester would be better understood through further research and experimentation, which could reveal its full potential in various scientific and industrial fields.

Upstream product

• 92486-65-2 diethyl trans-N-benzyl-pyrrolidine-3,4-dicarboxylate 
• 2459-05-4 (E)-4-ethoxy-4-oxobut-2-enoic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1268519-99-8 (3S*,4S*)-1-benzyl-pyrrolidine-3,4-dicarboxylic acid monoethyl ester 
• 623-91-6 diethyl Fumarate 
• 595547-23-2 (+/-)-trans-pyrrolidine-1,3,4-tricarboxylic acid 1-tert-butyl ester 3,4-diethyl ester 
• 128217-49-2 (4S)-3-((E)-3'-(Ethoxycarbonyl)-2'-propenoyl)-4-(phenylmethyl)-2-oxazolidinone 

Downstream Products

• 1782350-51-9 (3S,4S)-1-(tert-butoxycarbonyl)pyrrolidine-3,4-dicarboxylic acid 
• 865451-71-4 (3R,4R)-4-(4-chlorophenylcarbamoyl)pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester 
• 865451-74-7 (3R,4R)-4-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)phenylcarbamoyl]pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester 

Relevant academic research and scientific papers

TLR2 MODULATOR COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

The present disclosure relates to compounds which modulate the activity of Toll-like receptor (TLR) proteins, including agonists or activators, partial agonists, and antagonists. Of particular interest of compounds that modulate the activity of TLR2, as well as methods of using such compounds to treat cancer and other disorders associated with a TLR2 pathway.

PENTACYCLIC HETEROCYCLES

The present invention provides compounds represented by formulas (I) to (XVII) or pharmaceutically acceptable salts thereof:

TRIAZOLE-ISOXAZOLE COMPOUND AND MEDICAL USE THEREOF

A compound represented by Formula [I]: or pharmaceutically acceptable salt thereof, wherein each symbol is as defined in the description.

PROCESSES FOR THE PREPARATION OF (3R, 4R) -N- (4 -CHLOROPHENYL) -1- (2, 2-DIFLUOROETHYL) -N' - [2-FLUORO-4- (2-OXO-1 (2H) -PYRIDINYL) PHENYL] -3, 4-PYRROLIDINEDICARBOXAMIDE

The invention is concerned with processes for the manufacture of pyrrolidine-3,4- dicarboxamide derivative of formula (I), and the intermediates useful for those processes.

NEW SOLID FORMS OF FXA INHIBITORS

The invention is concerned with crystalline forms or amorphous forms of a pyrrolidine- 3,4-dicarboxamide derivative, which is useful as an active ingredient of medicaments for the diseases which can be treated by the coagulation factor Xa inhibitors.

3, 4-SUBSTITUTED PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF HYPERTENSION

The invention relates to the use of (3,4-di-, 3,3,4-tri, 3,4,4-tri- or 3,3,4,4-tetra-)substituted pyrrolidine compounds for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; compounds that are part of a subclass of these substituted pyrrolidine compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (= disorder) that depends on activity of renin; new compounds that are part of a subclass of these substituted pyrrolidine compounds; pharmaceutical formulations comprising said substituted pyrrolidine compounds, and/or a method of treatment comprising administering said substituted pyrrolidine compounds, a method for the manufacture especially of said new substituted pyrrolidine compounds, as well as novel intermediates, starting materials and/or partial steps for their synthesis. The substituted pyrrolidine compounds are of the formula (I), wherein R1, R2, R3, R4, R5 and T are defined as in the specification.

NOVEL PYRROLIDINE-3,4-DICARBOXAMIDE DERIVATIVES

The invention is concerned with novel pyrrolidine-3,4-dicarboxamide derivatives of Formula (I) ; wherein Rl to R9 and X are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These c

Chemoenzymatic preparation of non-racemic N-Boc-pyrrolidine-3,4-dicarboxylic acid 3-ethyl esters and their 4-hydroxymethyl derivatives

For the synthesis of metalloproteinase inhibitors the (R,R)- and (S,S)-monoethyl esters of N-Boc-pyrrolidine-3,4-dicarboxylic acid were prepared as key intermediates from the trans-diester racemate by two consecutive, highly selective enzymatic reactions.