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865451-74-7

(3R,4R)-4-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)phenylcarbamoyl]pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • (3R,4R)-4-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)phenylcarbamoyl]pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester

    Cas No: 865451-74-7

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  • 865451-74-7 Structure

  • Basic information

    1. Product Name: (3R,4R)-4-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)phenylcarbamoyl]pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester
    2. Synonyms: (3R,4R)-4-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)phenylcarbamoyl]pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester
    3. CAS NO:865451-74-7
    4. Molecular Formula:
    5. Molecular Weight: 473.501
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 865451-74-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (3R,4R)-4-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)phenylcarbamoyl]pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: (3R,4R)-4-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)phenylcarbamoyl]pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester(865451-74-7)
    11. EPA Substance Registry System: (3R,4R)-4-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)phenylcarbamoyl]pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester(865451-74-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 865451-74-7(Hazardous Substances Data)

865451-74-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 865451-74-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,5,4,5 and 1 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 865451-74:
(8*8)+(7*6)+(6*5)+(5*4)+(4*5)+(3*1)+(2*7)+(1*4)=197
197 % 10 = 7
So 865451-74-7 is a valid CAS Registry Number.

865451-74-7Relevant articles and documents

Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)- pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide} as a clinical candidate

Anselm, Lilli,Banner, David W.,Benz, J?rg,Groebke Zbinden, Katrin,Himber, Jacques,Hilpert, Hans,Huber, Walter,Kuhn, Bernd,Mary, Jean-Luc,Otteneder, Michael B.,Panday, Narendra,Ricklin, Fabienne,Stahl, Martin,Thomi, Stefan,Haap, Wolfgang

scheme or table, p. 5313 - 5319 (2010/10/21)

A series of (3R,4R)-pyrrolidine-3,4-dicarboxylic acid amides was investigated with respect to their factor Xa inhibitory activity, selectivity, pharmacokinetic properties, and ex vivo antithrombotic activity. The clinical candidate from this series, R1663

PROCESSES FOR THE PREPARATION OF (3R, 4R) -N- (4 -CHLOROPHENYL) -1- (2, 2-DIFLUOROETHYL) -N' - [2-FLUORO-4- (2-OXO-1 (2H) -PYRIDINYL) PHENYL] -3, 4-PYRROLIDINEDICARBOXAMIDE

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Page/Page column 31, (2008/12/06)

The invention is concerned with processes for the manufacture of pyrrolidine-3,4- dicarboxamide derivative of formula (I), and the intermediates useful for those processes.

NEW SOLID FORMS OF FXA INHIBITORS

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, (2009/01/20)

The invention is concerned with crystalline forms or amorphous forms of a pyrrolidine- 3,4-dicarboxamide derivative, which is useful as an active ingredient of medicaments for the diseases which can be treated by the coagulation factor Xa inhibitors.

NOVEL PYRROLIDINE-3,4-DICARBOXAMIDE DERIVATIVES

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Page/Page column 40, (2008/06/13)

The invention is concerned with novel pyrrolidine-3,4-dicarboxamide derivatives of Formula (I) ; wherein Rl to R9 and X are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These c

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