121353-01-3

Upstream product

• 776-88-5 5,5-dimethyl-2-phenyl-[1,3]dioxane 
• 126-30-7 2,2-Dimethyl-1,3-propanediol 
• 100-52-7 benzaldehyde 
• 121352-88-3 [(2R,3R)-3-(2-Benzyloxy-1,1-dimethyl-ethyl)-oxiranyl]-methanol 
• 121352-90-7 (E)-3-[(2R,3R)-3-(2-Benzyloxy-1,1-dimethyl-ethyl)-oxiranyl]-propenal 
• 121352-89-4 (2S,3R)-3-(2-Benzyloxy-1,1-dimethyl-ethyl)-oxirane-2-carbaldehyde 
• 121352-87-2 (E)-5-(benzyloxy)-4,4-dimethylpent-2-en-1-ol 
• 38216-93-2 3-benzyloxypivalic aldehyde 
• 66582-32-9 3-(benzyloxy)-2,2-dimethylpropan-1-ol 
• 121353-00-2 (S)-4-[(4R,6S)-6-(2-Benzyloxy-1,1-dimethyl-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-butane-1,3-diol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 121352-94-1 2,2-Dimethyl-propionic acid 2-[(4R,6S)-6-(2-benzyloxy-1,1-dimethyl-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-ethyl ester 
• 121352-99-6 {(2R,3R)-3-[(4S,6S)-6-(2-Benzyloxy-1,1-dimethyl-ethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-oxiranyl}-methanol 
• 121352-93-0 2,2-Dimethyl-propionic acid (3R,5S)-7-benzyloxy-3,5-dihydroxy-6,6-dimethyl-heptyl ester 

Downstream Products

• 121353-16-0 (S)-7-[2-(tert-Butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-{(4S,6R)-6-[(S)-4-(tert-butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-5-hydroxy-2-methyl-dec-9-en-3-one 
• 121353-16-0 (R)-7-[2-(tert-Butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-{(4S,6R)-6-[(S)-4-(tert-butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-5-hydroxy-2-methyl-dec-9-en-3-one 
• 111070-65-6 3-{(4S,6R)-6-[(S)-4-(tert-Butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-3-methyl-butan-2-one 
• 121353-02-4 2-{(4S,6R)-6-[(S)-4-(tert-Butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-2-methyl-propionaldehyde 
• 121353-03-5 3-{(4S,6R)-6-[(S)-4-(tert-Butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-3-methyl-butan-2-ol 
• 111043-56-2 2-{(4S,6R)-6-[(S)-4-(tert-Butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-2-methyl-propan-1-ol 

Relevant academic research and scientific papers

Synthesis of Bryostatins. 1. Construction of the C(1)-C(16) Fragment

The synthesis of fragment AB of bryostatin 1 is described.Two aldol coupling reactions involving (i) chiral fragment A with achiral B and (ii) chiral fragment A1 with achiral A2 constitute crucial steps in which an external chiral boron reagent is used to control stereoselectivity in the creation of a new stereogenic center.This type of double asymmetric synthesis, although rarely precedented, provides a powerful means of stereocontrol over the fragment assembly.