111070-65-6

Basic information

• Product Name: 3-{(4S,6R)-6-[(S)-4-(tert-Butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-3-methyl-butan-2-one
• Synonyms: 3-{(4S,6R)-6-[(S)-4-(tert-Butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-3-methyl-butan-2-one
• CAS NO: 111070-65-6
• Molecular Weight: 570.842
• Mol File: 111070-65-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-{(4S,6R)-6-[(S)-4-(tert-Butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-3-methyl-butan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-{(4S,6R)-6-[(S)-4-(tert-Butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-3-methyl-butan-2-one(111070-65-6)
• EPA Substance Registry System: 3-{(4S,6R)-6-[(S)-4-(tert-Butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-3-methyl-butan-2-one(111070-65-6)

Safety Data

• Hazardous Substances Data: 111070-65-6(Hazardous Substances Data)

Upstream product

• 776-88-5 5,5-dimethyl-2-phenyl-[1,3]dioxane 
• 121352-93-0 2,2-Dimethyl-propionic acid (3R,5S)-7-benzyloxy-3,5-dihydroxy-6,6-dimethyl-heptyl ester 
• 121353-00-2 (S)-4-[(4R,6S)-6-(2-Benzyloxy-1,1-dimethyl-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-butane-1,3-diol 
• 121352-99-6 {(2R,3R)-3-[(4S,6S)-6-(2-Benzyloxy-1,1-dimethyl-ethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-oxiranyl}-methanol 
• 121352-94-1 2,2-Dimethyl-propionic acid 2-[(4R,6S)-6-(2-benzyloxy-1,1-dimethyl-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-ethyl ester 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 126-30-7 2,2-Dimethyl-1,3-propanediol 
• 121353-10-4 (3S,5S,7S)-1-Benzyloxy-9-(tert-butyl-diphenyl-silanyloxy)-7-methoxymethoxy-2,2-dimethyl-nonane-3,5-diol 
• 121353-05-7 (S)-5-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxy-pentanethioic acid S-(1,1-diethyl-propyl) ester 
• 121352-88-3 [(2R,3R)-3-(2-Benzyloxy-1,1-dimethyl-ethyl)-oxiranyl]-methanol 
• 121372-79-0 {(S)-4-[(4R,6S)-6-(2-Benzyloxy-1,1-dimethyl-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-3-methoxymethoxy-butoxy}-tert-butyl-diphenyl-silane 
• 121353-08-0 (S)-1-Benzyloxy-9-(tert-butyl-diphenyl-silanyloxy)-3-hydroxy-7-methoxymethoxy-2,2-dimethyl-nonan-5-one 
• 121353-01-3 (S)-1-[(4R,6S)-6-(2-Benzyloxy-1,1-dimethyl-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-4-(tert-butyl-diphenyl-silanyloxy)-butan-2-ol 
• 121353-02-4 2-{(4S,6R)-6-[(S)-4-(tert-Butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-2-methyl-propionaldehyde 

Downstream Products

• 121353-16-0 (R)-7-[2-(tert-Butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-{(4S,6R)-6-[(S)-4-(tert-butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-5-hydroxy-2-methyl-dec-9-en-3-one 
• 121353-16-0 (S)-7-[2-(tert-Butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-{(4S,6R)-6-[(S)-4-(tert-butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-5-hydroxy-2-methyl-dec-9-en-3-one 

Relevant articles and documents

Synthesis of Bryostatins. 1. Construction of the C(1)-C(16) Fragment

The synthesis of fragment AB of bryostatin 1 is described.Two aldol coupling reactions involving (i) chiral fragment A with achiral B and (ii) chiral fragment A1 with achiral A2 constitute crucial steps in which an external chiral boron reagent is used to control stereoselectivity in the creation of a new stereogenic center.This type of double asymmetric synthesis, although rarely precedented, provides a powerful means of stereocontrol over the fragment assembly.