1213786-20-9

Upstream product

• 583-55-1 1-Bromo-2-iodobenzene 
• 213599-19-0 1-bromo-2-(2,2-dibromovinyl)benzene 
• 6630-33-7 ortho-bromobenzaldehyde 
• 52670-38-9 2-ethynylaniline 
• 766-46-1 2-bromo-1-ethynylbenzene 
• 95-53-4 o-toluidine 
• 38274-16-7 2-bromo-1-(trimethylsilylethynyl)benzene 
• 615-43-0 2-iodophenylamine 
• 103529-16-4 2-[(trimethylsilyl)ethynyl]aniline 

Downstream Products

• 1213786-07-2 2-(2-bromophenyl)-3-(phenylthio)-1H-indole 
• 1224635-22-6 2-{[2-(3,3-dimethylbut-1-ynyl)phenyl]ethynyl}aniline 
• 1224635-19-1 2-{[2-(pent-1-ynyl)phenyl]ethynyl}aniline 
• 1224635-20-4 2-{[2-(cyclohexylethynyl)phenyl]ethynyl}aniline 
• 1224635-24-8 2-({2-[(4-methoxyphenyl)ethynyl]phenyl}ethynyl)aniline 
• 852619-15-9 2-({2-[(trimethylsilyl)ethynyl]phenyl}ethynyl)aniline 
• 1224635-23-7 2-{[2-(p-tolylethynyl)phenyl]ethynyl}aniline 
• 1236003-92-1 (Z)-4-(2-bromobenzylidene)-N,N-dimethyl-4H-benzo[d][1,3]thiazin-2-amine 
• 1570214-73-1 2-(2-bromophenyl)-3,3-difluoro-3H-indole 

Relevant academic research and scientific papers

Palladium-Catalyzed Cascade Arene/Alkyne Annulation: Synthesis of Fluorene-Benzoxazine Derivatives

A palladium-catalyzed cascade arene/alkyne annulation reaction for the synthesis of fluorene-benzoxazine derivatives is developed. This transformation involves a 6-exo-dig cyclization, a 1,3-oxazine vinylpalladium intermediate, and a C-H bond activation.

Cascade Synthesis of Benzothieno[3,2- b]indoles under Oxidative Conditions Mediated by CuBr and tert-Butyl Hydroperoxide

A series of biologically relevant compounds of benzothieno[3,2-b]indole derivatives were conveniently synthesized from reactions of N-protected 2-((2-bromophenyl)ethynyl)anilines and potassium ethylxanthate, mediated by cuprous bromide/tert-butyl hydroper

Copper-Catalyzed Enantioselective C-H Arylation between 2-Arylindoles and Hypervalent Iodine Reagents

The copper-catalyzed enantioselective C-H arylation between 2-arylindoles and hypervalent iodine reagents has been successfully developed, which provides a convenient and economical route to the highly atroposelective synthesis of axially chiral indole de

Solvent-Dependent Cyclization of 2-Alkynylanilines and ClCF2COONa for the Divergent Assembly of N-(Quinolin-2-yl)amides and Quinolin-2(1 H)-ones

Herein, we present an expedient Cu-catalyzed [5 + 1] cyclization of 2-alkynylanilines and ClCF2COONa to divergent construction of N-(quinolin-2-yl)amides and quinolin-2(1H)-ones by regulating the reaction solvents. Notably, nitrile acts as a solvent and performs the Ritter reactions. ClCF2COONa is used as a C1 synthon in this transformation, which also represents the first example for utilization of ClCF2COONa as an efficient desiliconization reagent. The current protocol involves in situ generation of isocyanide, copper-activated alkyne, Ritter reaction and protonation.

Copper-catalyzed (4+1) and (3+2) cyclizations of iodonium ylides with alkynes

The copper(ii)-catalyzed (4+1) cyclizations and copper(i)-catalyzed (3+2) cycloadditions of iodonium ylides and alkynes were successfully developed by employing efficient and safe iodonium ylides instead of traditional diazo compounds. Highly functionaliz

Cs2CO3 as a source of carbonyl and ethereal oxygen in a Cu-catalysed cascade synthesis of benzofuran [3,2-: C] quinolin-6[5- H] ones

The simultaneous construction of C-C, C-O, and C-N bonds utilizing Cs2CO3 as a source of both carbonyl (CO) and ethereal oxygen and a cascade synthesis of benzofuro[3,2-c]quinolin-6(5H)-one have been achieved using a combination of C

Silver-catalyzed one-pot cyclization/fluorination of 2-alkynylanilines: Highly efficient synthesis of structurally diverse fluorinated indole derivatives

Highly efficient approaches to obtain structurally diverse fluorinated indole derivatives have been realized through the Ag-catalyzed one-pot cyclization/fluorination of 2-alkynylanilines in the presence of NFSI or Selectfluor. The Royal Society of Chemistry.

Palladium-catalyzed intermolecular aerobic oxidative cyclization of 2-ethynylanilines with isocyanides: Regioselective synthesis of 4-halo-2-aminoquinolines

A robust and regioselective palladium-catalyzed intermolecular aerobic oxidative cyclization of 2-ethynylanilines with isocyanides to the synthesis of 4-halo-2-aminoquinolines is reported herein. The procedure constructs various 4-halo-2-aminoquinolines w

Gold-catalyzed intramolecular alkyne cycloisomerization cascade: Direct synthesis of aryl-annulated[a]carbazoles from aniline-substituted diethynylarenes

Aniline-substituted diethynylarenes, which are readily synthesized through Sonogashira coupling reactions from commercially available 1,2-dihaloarenes, directly produce aryl- and heteroaryl-annulated [a]carbazoles by the gold-catalyzed intramolecular casc

3-(2-Alken-1-one-2-yl)indoles through the palladium-catalyzed reaction of 2-alkynyltrifluoroacetanilides with cyclic α-iodoenones

α-Iodoenones can be efficiently employed as organic electrophiles in the Pd-catalyzed synthesis of 2,3-disubstituted indoles from 2-alkynyltrifluoroacetanilides. Best results were obtained using the weak ligand As(Ph)3. The methodology reported provides an efficient entry to indoles bearing a 2-alkenon-2-yl moiety linked in the 3-position, that possesses a scarcely reported substitution pattern.