1213855-88-9

Basic information

• Product Name: (R)-methyl 2-amino-2-(5-bromo-2-fluorophenyl)propanoate
• Synonyms: (R)-methyl 2-amino-2-(5-bromo-2-fluorophenyl)propanoate
• CAS NO: 1213855-88-9
• Molecular Formula: C₁₀H₁₁BrFNO₂
• Molecular Weight: 276.1022432
• Mol File: 1213855-88-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-methyl 2-amino-2-(5-bromo-2-fluorophenyl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-methyl 2-amino-2-(5-bromo-2-fluorophenyl)propanoate(1213855-88-9)
• EPA Substance Registry System: (R)-methyl 2-amino-2-(5-bromo-2-fluorophenyl)propanoate(1213855-88-9)

Safety Data

• Hazardous Substances Data: 1213855-88-9(Hazardous Substances Data)

Upstream product

• 198477-89-3 1-(5-bromo-2-fluorophenyl)ethan-1-one 
• 67-56-1 methanol 
• 1266784-23-9 (RS)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid 
• 1350523-51-1 rac-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionitrile 

Downstream Products

• 1443035-31-1 C₉H₈BrFNO₂^(1-)*Na⁽¹⁺⁾ 
• 1443035-33-3 C₁₁H₉BrClFNO₃^(1-)*Na⁽¹⁺⁾ 
• 1443035-35-5 (3R)-3-(5-bromo-2-fluorophenyl)-3-methylmorpholine-2,5-dione 
• 1443035-37-7 C₁₂H₁₀BrF₄NO₃ 
• 1443035-39-9 (5R)-5-(5-bromo-2-fluorophenyl)-6-chloro-5-methyl-6-(trifluoromethyl)morpholin-3-one 
• 1443035-41-3 (5R)-5-(5-bromo-2-fluorophenyl)-6-(difluoromethylene)-5-methylmorpholin-3-one 
• 1443035-43-5 (5R)-5-(5-bromo-2-fluorophenyl)-6-(difluoromethylene)-5-methylmorpholin-3-thione 
• 1443259-48-0 (5R)-5-(5-bromo-2-fluorophenyl)-5-methyl-6-(trifluoromethyl)-morpholin-3-one 
• 1352419-89-6 (5R)-5-(5-bromo-2-fluoro-phenyl)-5-methyl-6-(trifluoromethyl)-morpholine-3-thione 
• 1443259-50-4 (5R,6S)-5-(5-bromo-2-fluorophenyl)-5-methyl-6-(trifluoromethyl)-2,6-dihydro-1,4-oxazin-3-amine 
• 1443259-26-4 (5R,6R)-5-{2-fluoro-5-[(3-methoxypyridin-2-yl)amino]phenyl}-5-methyl-6-(trifluoromethyl)-5,6-dihydro-2H-1,4-oxazin-3-amine 
• 1443259-27-5 (5R,6R)-5-[2-fluoro-5-(pyrimidin-2-ylamino)phenyl]-5-methyl-6-(trifluoromethyl)-5,6-dihydro-2H-1,4-oxazin-3-amine 
• 1443259-31-1 2-((3-((2R,3R)-5-amino-3-methyl-2-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl)amino)nicotinonitrile 
• 1443035-45-7 (5R)-5-(5-bromo-2-fluorophenyl)-6-(difluoromethylene)-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine 

Relevant articles and documents

5-ARYL-1-IMINO-1-OXO-[1,2,4]THIADIAZINES

The present invention provides a compound of formula I' having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are

5-AMINO[1,4]THIAZINES AS BACE 1 INHIBITORS

The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.

6-DIFLUOROMETHYL-5,6-DIHYDRO-2H-[1,4]OXAZIN-3-AMINE DERIVATIVES

The invention relates to novel 6-difluoromethyl-5,6-dihydro-2H-[l,4]oxazin-3- amine derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceut