121424-20-2

Upstream product

• 18439-60-6 methyl 2,3,4-tri-O-acetyl-6-O-p-toluenesulfonyl-α-D-mannopyranoside 
• 64-19-7 acetic acid 
• 108-24-7 acetic anhydride 
• 51103-66-3 methyl 6-O-(p-tolylsulfonyl)-α-D-mannopyranoside 
• 51008-88-9 1,2,3,4-tetra-O-acetyl-D-mannopyranoside 
• 98-59-9 p-toluenesulfonyl chloride 
• 6619-07-4 6-O-p-toluenesulfonyl-D-mannopyranose 
• 530-26-7 D-Mannose 
• 3458-28-4 D-Mannose 
• 617-04-9 (2R,3S,4S,5S,6S)-2-(hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol 

Downstream Products

• 1473360-05-2 p-tolyl 6-azido-2,3,4-tri-O-acetyl-6-deoxy-1-thio-α-D-mannopyranoside 
• 1473360-07-4 p-tolyl 6-azido-2,3,4-tri-O-benzoyl-6-deoxy-1-thio-α-D-mannopyranoside 
• 863915-11-1 6-azido-2,3,4-tri-O-benzoyl-6-deoxy-α-D-mannopyranose-1-O-trichloroacetimidate 
• 1473360-15-4 6-azido-2,3,4-tri-O-benzyl-6-deoxy-α-D-mannopyranose-1-O-trichloroacetimidate 
• 1473360-01-8 3-O-(6'-azido-2',3',4'-tri-O-benzoyl-6'-deoxy-α-D-mannopyranosyl)-1,2-isopropylidene-sn-glycerol 
• 1473360-18-7 3-O-(6'-amino-2',3',4'-tri-O-benzyl-6'-deoxy-α-D-mannopyranosyl)-sn-glycerol 
• 1473360-19-8 1,2-dihexanoyl-3-O-(N-hexanoyl-6'-amino-2',3',4'-tri-O-benzyl-6'-deoxy-α-D-mannopyranosyl)-sn-glycerol 
• 1473360-20-1 1,2-dioctanoyl-3-O-(N-octanoyl-6'-amino-2',3',4'-tri-O-benzyl-6'-deoxy-α-D-mannopyranosyl)-sn-glycerol 

Relevant academic research and scientific papers

Pathways in the synthesis of functionalized glycolipids for liposomal preparations

We describe in this paper the synthesis of two glycolipids containing a mannosyl residue functionalized with malonic acid and azide groups at the C6 position. Two synthetic routes have been successfully implemented: the first one involves Schmidt's glycosylation procedure using functionalized carbohydrates, whereas the second one involves nucleophilic substitutions in the C6 position of an iodinated intermediate obtained using Koenigs-Knorr reaction. A comparative discussion of reactions and yields is realized. The two glycolipids served as material for the preparation of liposomes.

D - And L -Mannose-Containing glyco-Oligoamides Show Distinct Recognition Properties When Interacting with DNA

Mannose glyco-oligoamide β-D-Man-Py-γ-Py-Ind (β-D-Man, 1) and two new glyco-oligoamides, β-L-Man-Py-γ-Py-Ind (β-L-Man, 2) and 6-deoxy-β-D-Man-Py-γ-Py-Ind (6-deoxy-β-D-Man, 3), have been designed and synthesized to investigate the role of hydrogen-bonding

Synthesis and antiviral evaluation of 6'-acylamido-6'-deoxy-α-d- mannoglycerolipids

Eight new aminomannoglycerolipids (2a-h) with linear, branched, or aromatic acyl chains were synthesized and evaluated for their anti-influenza A virus (IAV) activity. By comparing six mannosyl donors with different protecting and leaving groups, the critical glycosylation reaction employed mannosyl trichloroacetimidate with 2-O-benzoyl protecting group as the donor to give the glycoside with absolute α-anomeric selectivity. The bioactivity results showed that the branched compound 2g could effectively inhibit IAV multiplication in MDCK cells with IC50 69.9 μM.

The synthesis of various 1,6-disulfide-B ridged D-hexopyranoses

1,6-Disulfide-bridged derivatives have been prepared for D-gluco-, D-manno-, D-allo-, D-galacto-, and D-talopyranose, in the main by the nucleophilic attack of a C6 thiolate onto an anomeric thiosulfonate. The D-gluco disulfide, 'angyalosan', was successfully oxidized to a single thiosulfinate. CSIRO 2005.

Building Units of Oligosaccharides, CX. - Synthesis of Potential Inhibitors of N-Acetylglucosaminyltransferase I

Modified derivatives of the trisaccharide octyl α-D-Man(1-->3)-6)>-β-D-Man were synthesized by attaching reactive groups via a pentyl spacer to the 4'-OH and 6'-OH group.Glycosylation steps were carried out by using the trichloroacetimidate m