1214353-79-3

Basic information

• Product Name: Methyl 5-broMo-6-chloropyridine-2-carboxylate
• Synonyms: Methyl 5-broMo-6-chloropyridine-2-carboxylate;Methyl 5-broMo-6-chloropicolinate
• CAS NO: 1214353-79-3
• Molecular Formula: C₇H₅BrClNO₂
• Molecular Weight: 250.4771
• Mol File: 1214353-79-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 338.8±37.0 °C(Predicted)
• Appearance: /
• Density: 1.684±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -3.38±0.10(Predicted)
• CAS DataBase Reference: Methyl 5-broMo-6-chloropyridine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 5-broMo-6-chloropyridine-2-carboxylate(1214353-79-3)
• EPA Substance Registry System: Methyl 5-broMo-6-chloropyridine-2-carboxylate(1214353-79-3)

Safety Data

• Hazardous Substances Data: 1214353-79-3(Hazardous Substances Data)

Usage

General Description

Methyl 5-bromo-6-chloropyridine-2-carboxylate is a chemical compound with the molecular formula C7H5BrClNO2. It is a derivative of pyridine and contains bromine, chlorine, and a carboxylate functional group. Methyl 5-broMo-6-chloropyridine-2-carboxylate is used in the synthesis of various pharmaceuticals and agrochemicals due to its potential as a building block in organic chemistry. It can undergo different chemical reactions to form new compounds with a wide range of potential applications in the pharmaceutical and agricultural industries. However, it is important to handle this chemical with caution due to its potential health hazards and flammability.

Upstream product

• 67-56-1 methanol 
• 959741-37-8 5-bromo-2-carboxypyridin-1-ium-1-olate 
• 30766-11-1 5-bromoisonicotinic acid 
• 959741-32-3 5-bromo-2-(methoxycarbonyl)-1^A[5]-pyridin-1-olate 
• 29682-15-3 methyl 5-bromopicolinate 

Downstream Products

• 1415898-29-1 5-cyclopropyl-6-(2,4-dichloro-phenylamino)-pyridine-2-carboxylic acid 
• 1415899-33-0 6-(3-chloro-phenyl)-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid 
• 959958-25-9 5-bromo-6-chloropyridine-2-carboxylic acid 

Relevant articles and documents

TRIAZOLOPYRIMIDINE DERIVATIVES FOR USE AS GHRELIN O-ACYL TRANSFERASE (GOAT) INHIBITORS

The present invention relates to compounds of general formula I, wherein the groups R1 and R2 are defined as in claim 1, which have valuable pharmacological properties, in particular bind to ghrelin O-acyl transferase (GOAT) and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular obesity.

Discovery of a high affinity and selective pyridine analog as a potential positron emission tomography imaging agent for cannabinoid type 2 receptor

As part of our efforts to develop CB2 PET imaging agents, we investigated 2,5,6-substituted pyridines as a novel class of potential CB2 PET ligands. A total of 21 novel compounds were designed, synthesized, and evaluated for their potency and binding properties toward human and rodent CB1 and CB2. The most promising ligand 6a was radiolabeled with carbon-11 to yield 16 ([11C]RSR-056). Specific binding of 16 to CB2-positive spleen tissue of rats and mice was demonstrated by in vitro autogadiography and verified in vivo in PET and biodistribution experiments. Furthermore, 16 was evaluated in a lipopolysaccharid (LPS) induced murine model of neuroinflammation. Brain radioactivity was strikingly higher in the LPS-treated mice than the control mice. Compound 16 is a promising radiotracer for imaging CB2 in rodents. It might serve as a tool for the investigation of CB2 receptor expression levels in healthy tissues and different neuroinflammatory disorders in humans.

AROMATIC RING COMPOUND

Provided is an aromatic ring compound having a GPR40 agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity, and is useful as an agent for the prophylaxis or treatment of diabetes and the like.