1215-50-5

Basic information

• Product Name: 3-Anilino-1-phenyl-2-propen-1-one
• Synonyms: 3-Anilino-1-phenyl-2-propen-1-one
• CAS NO: 1215-50-5
• Molecular Formula: C₁₅H₁₃NO
• Molecular Weight: 223.26982
• Mol File: 1215-50-5.mol

Chemical Properties

• Melting Point: 139-140 °C
• Boiling Point: 358.0±38.0 °C(Predicted)
• Appearance: /
• Density: 1.145±0.06 g/cm3(Predicted)
• PKA: 0.80±0.70(Predicted)
• CAS DataBase Reference: 3-Anilino-1-phenyl-2-propen-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Anilino-1-phenyl-2-propen-1-one(1215-50-5)
• EPA Substance Registry System: 3-Anilino-1-phenyl-2-propen-1-one(1215-50-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1215-50-5(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 3623-15-2 phenyl propargyl ketone 
• 70769-76-5 3-ethylsulfanyl-1-phenyl-propenone 
• 72374-71-1 N-(2,2-dichloro-1-phenyl-1-propylidene)aniline 
• 142-04-1 aniline hydrochloride 
• 15397-33-8 3-Oxo-3-phenylpropanal 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 98-86-2 acetophenone 
• 1201-93-0 1-phenyl-3-dimethylaminoprop-2-enone 
• 1131-80-2 (E)-3-(N,N-dimethylamino)-1-phenyl-2-propen-1-one 
• 6780-49-0 ethyl N-phenylformimidate 
• 1197040-29-1 phenyl isocyanate 
• 3592-47-0 Benzaldehyde-d 
• 70485-98-2 (E)-3-(diisopropylamino)-1-phenylprop-2-en-1-one 

Downstream Products

• 612-96-4 2-Phenylquinoline 
• 6831-89-6 1,5-diphenyl-1H-pyrazole 
• 98422-07-2 Bis-<2-anilino-1-benzoyl-vinyl>-sulfid 
• 98-86-2 acetophenone 
• 121-57-3 4-aminobenzene sulfonic acid 
• 1134192-90-7 1,4-diphenyl-3-benzoyl-1,4-dihydropyridine 
• 1401855-90-0 ((4S,6R)-6-hydroxy-1,4-diphenyl-1,4,5,6-tetrahydropyridin-3-yl)(phenyl)methanone 
• 1401856-14-1 (S)-(1,4-diphenyl-1,4-dihydropyridin-3-yl)(phenyl)methanone 
• 1401856-17-4 (S)-5-benzoyl-1,4-diphenyl-3,4-dihydropyridin-2(1H)-one 
• 1401856-11-8 ((4S,6R)-6-hydroxy-4-(4-methoxyphenyl)-1-phenyl-1,4,5,6-tetrahydropyridin-3-yl)(phenyl)methanone 
• 1401856-10-7 ((4S,6R)-6-hydroxy-4-(2-methoxyphenyl)-1-phenyl-1,4,5,6-tetrahydropyridin-3-yl)(phenyl)methanone 

Relevant articles and documents

An atom-economic green approach: Oxidative synthesis of functionalized 1,4-dihydropyridines from N,N-dimethylenaminones and amines

We report the first oxidative condensation between N,N-dimethylenaminones with amines to form 1,4-dihydropyridines in moderate to good yields, promoted by oxone and trifluoroacetic acid in PEG-400. This reaction features an unusual oxidation of in situ fo

Mannich Reaction with Enaminones: Convenient Synthesis of Functionalized Tetrahydro-pyrimidines, Dihydro-1,3-oxazines, and Dihydro-1,2,4-triazepines

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The development of a mild, low cost and green synthetic route for covalent organic frameworks (COFs) is highly desirable in order to open the door for practical uses of this new family of crystalline porous solids. Herein, we report a general and facile strategy to prepare a series of microporous or mesoporous COFs by a β-ketoenamine based Michael addition-elimination reaction in aqueous systems at ambient temperature and pressure. This synthesis method not only produces highly crystalline and porous COFs, but also can be carried out with a high reaction rate (only 30 min), high yields (as high as 93%) and large-scale preparation (up to 5.0 g). Furthermore, an Fe(ii)-doped COF shows impressive performance in the oxidative degradation of organic pollutants in aqueous medium. This research thus provides a promising pathway to large-scale green preparation of COFs and their potential application in environmental remediation.

Visible Light-Induced Thiocyanation of Enaminone C-H Bond to Access Polyfunctionalized Alkenes and Thiocyano Chromones

The visible light induced C-H bond thiocyanation on the α-site of tertiary enaminones has been realized under metal-free, photocatalytic conditions in the presence of Rose Bengal, which enables the synthesis of thiocyanated alkene derivatives and chromones using NH4SCN as the thiocyano source under an aerobic atmosphere. In addition, employing Ru(bpy)3Cl2·6H2O as the photocatalyst switches the reaction pathway to provide NH2-functionalized thiocyanated enamines via the difunctionalization process consisting of C-H bond thiocyanation and vinyl C-N bond transamination.

Copper-catalyzed carbene insertion and ester migration for the synthesis of polysubstituted pyrroles

Copper-catalyzed carbene insertion/ester migration/cyclization of enaminones and α-diazo compounds occurred efficiently to afford 2-ester polysubstituted pyrroles under mild conditions in moderate-to-good yields. Substituent functionality was well tolerated and13C-labelled experiments demonstrated 1,2-ester migration during the reaction.

Metal-free, green and efficient oxidative α halogenation of enaminones by halo acid and DMSO

Metal free oxidative halogenation of N-aryl enaminones has been demonstrated using a DMSO-halo acid combination under mild reaction conditions. This strategy allows a facile halogenation of enaminones through α functionalization leading to a broad range o

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Transition-metal-free synthesis of β-trifluoromethylated enamines with trifluoromethanesulfinate

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Organocatalytic activation of isocyanides: N-heterocyclic carbene-catalyzed enaminone synthesis from ketones

The first example of the use of an N-heterocyclic carbene (NHC) as an organocatalyst for the activation of isocyanides was demonstrated. On the basis of previous reports on the interaction between NHCs and isocyanides, we developed a catalytic cycle invol

Base-Promoted Synthesis of N-Substituted 1,2,3-Triazoles via Enaminone-Azide Cycloaddition Involving Regitz Diazo Transfer

The domino reactions between NH-based secondary enaminones and tosyl azide have been developed for the synthesis of various N-substituted 1,2,3-triazoles by employing t-BuONa as the base promoter. Through a key Regitz diazo-transfer process with tosyl azi