70485-98-2

Upstream product

• 2579-22-8 Phenylpropargyl aldehyde 
• 108-18-9 diisopropylamine 
• 3592-47-0 Benzaldehyde-d 
• 75-20-7 calcium carbide 
• 100-52-7 benzaldehyde 

Downstream Products

• 3506-54-5 3-(diethylamino)-1-phenylprop-2-en-1-one 
• 4452-12-4 1-phenyl-3-(piperidin-1-yl)prop-2-en-1-one 
• 14376-90-0 3-(benzylamino)-1-phenylprop-2-en-1-one 
• 19134-41-9 3-(butylamino)-1-phenylprop-2-en-1-one 
• 1215-50-5 1-phenyl-3-(phenylamino)prop-2-en-1-one 
• 15753-58-9 1-phenyl-3-(pyridin-3-ylamino)prop-2-en-1-one 
• 3453-00-7 diethyl benzoylmethylphosphonate 

Relevant academic research and scientific papers

Highly regioselective synthesis of cis-β-enaminones by 1,4-addition of propiolaldehydes

A convenient one-pot strategy for the regioselective synthesis of cis-β-enaminones has been developed via the condensation of propiolaldehydes and amines in EtOH. This process has opened a new synthetic route to enamines in good yield. A possible reaction mechanism involving a Michael addition/enol tautomerization via a six-membered ring transition state is proposed.

Acetylide Ion (C22-) as a synthon to link electrophiles and nucleophiles: A simple method for enaminone synthesis

Friendly competition: A three-component reaction system composed of calcium carbide, an aryl aldehyde, and an amine gave enaminones or propargylamines (see picture) in a predictable manner through competitive pathways. The system enables the cost-efficient synthesis of a variety of enaminones from readily accessible small molecules and demonstrates the versatility of the acetylide ion, which can be used to bridge electrophiles and nucleophiles. Copyright

PROCESS FOR PRODUCING AN AMINOPROPYNE OR ENAMINONE

There is provided a process for producing an aminopropyne or an enaminone comprising the step of reacting a metal acetylide, an amine and a carbonyl-containing compound in the presence of a transition metal catalyst. There is also provided a process for producing an aminopropyne comprising the step of reacting a metal acetylide, an amine and a halide-containing compound in the presence of a transition metal catalyst at a reaction temperature of 50°C to 150°C. There are also provided processes to further synthesize the aminopropyne produced to obtain a butyneamine, another aminopropyne or a triazol.