128540-53-4Relevant academic research and scientific papers
A Practical Synthesis of threo-3-Amino-2-hydroxycarboxylic Acids
Matsuda, Fuyuhiko,Mtsumoto, Teruyo,Ohsaki, Masako,Ito, Yoshio,Terashima, Shiro
, p. 360 - 365 (2007/10/02)
An expeditious synthesis of (2R,3S)-3-amino-4-cyclohexyl-2-hydroxybutyric acid (2) and (2S,3R)-3-amino-2-hydroxy-4-phenylbutyric acid (4), the key components of the renin inhibitor (1) and bestatin (3), respectively, have been accomplished by featuring hi
A highly stereoselective synthesis of (3S,4S)-statine and (3S,4S)-cyclohexylstatine
Takemoto,Matsumoto,Ito,Terashima
, p. 2425 - 2428 (2007/10/02)
The title compounds, which are synthetic intermediates of renin inhibitors, could be prepared from (S)-leucine and (S)-phenylalanine, respectively, by employing highly stereoselective aldol reactions of O-methyl-O-trimethylsilyl ketene acetal with an (S)-
An expeditious synthesis of (3S,4S)-statine and (3S,4S)cyclohexylstatine
Takemoto, Yoshiji,Matsumoto, Teruyo,Ito, Yoshio,Terashima, Shiro
, p. 217 - 218 (2007/10/02)
The title synthesis could be accomplished by employing highly stereoselective aldol reaction of O-methyl-O-trimethylsilyl ketene acetal with the (S)-α-amido aldehyde (2) in the presence of titanium (IV) chloride as a key step.
A Practical Synthesis of an Orally Potent Renin Inhibitor, Isopropyl (2R,3S)-4-Cyclohexyl-2-hydroxy-3--L-histidyl>aminobutyrate
Harada, Hiromu,Iyobe, Akira,Tsubaki, Atsushi,Yamaguchi, Toshiaki,Hirata, Kazuma,et al.
, p. 2497 - 2500 (2007/10/02)
The practical synthesis of an orally potent human renin inhibitor, isopropyl (2R,3S)-4-cyclohexyl-2-hydroxy-3--L-histidyl>aminobutyrate, is presented.Optically pure cyclohexylnorstatine isopropyl
