1380650-63-4

Basic information

• Product Name: 1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester
• Synonyms: 1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester
• CAS NO: 1380650-63-4
• Molecular Weight: 510.59
• Mol File: 1380650-63-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester(1380650-63-4)
• EPA Substance Registry System: 1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester(1380650-63-4)

Safety Data

• Hazardous Substances Data: 1380650-63-4(Hazardous Substances Data)

Upstream product

• 1517-69-7 (R)-1-phenylethanol 
• 1228690-37-6 (R)-1-phenylethyl (5-(4-bromophenyl)-3-methylisoxazol-4-yl)carbamate 
• 1257213-52-7 1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropane-1-carboxylic acid ethyl ester 
• 91182-60-4 5-(4-bromophenyl)-3-methylisoxazole-4-carboxylic acid 
• 1215205-50-7 ethyl 1-(4-bromophenyl)cyclopropane-1-carboxylate 
• 1159489-46-9 [4-(1'-carboxycyclopropyl)phenyl]boronic acid 
• 345965-52-8 1-(4-bromophenyl)cyclopropanecarboxylic acid 
• 1380650-62-3 benzyl 5-(4'-(1-(ethoxycarbonyl)cyclopropyl)biphenyl-4-yl)-3-methylisoxazole-4-carboxylate 
• 1380650-61-2 ethyl 1-(4'-(2-(benzyloxycarbonyl)-3-(methylamino)but-2-enoyl)biphenyl-4-yl)cyclopropanecarboxylate 
• 1380650-58-7 4'-(1-(ethoxycarbonyl)cyclopropyl)biphenyl-4-carboxylic acid 
• 1380650-56-5 1-(4'-acetylbiphenyl-4-yl)cyclopropanecarboxylic acid ethyl ester 
• 1380650-55-4 ethyl 1-(4-phenylphenyl)cyclopropanecarboxylate 
• 93022-07-2 1-(biphenyl-4-yl)cyclopropanecarboxylic acid 
• 92855-14-6 1-(biphenyl-4-yl)cyclopropanecarbonitrile 

Downstream Products

• 1257213-50-5 (R)-1-(4'-(3-methyl-4-(((1-phenylethoxy)carbonyl)amino)isoxazol-5-yl)-[1,1'-biphenyl]-4-yl)cyclopropane-1-carboxylic acid 
• 1380650-53-2 1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid sodium salt 

Relevant articles and documents

Development of a Concise Multikilogram Synthesis of LPA-1 Antagonist BMS-986020 via a Tandem Borylation-Suzuki Procedure

The process development for the synthesis of BMS-986020 (1) via a palladium catalyzed tandem borylation/Suzuki reaction is described. Evaluation of conditions culminated in an efficient borylation procedure using tetrahydroxydiboron followed by a tandem Suzuki reaction employing the same commercially available palladium catalyst for both steps. This methodology addressed shortcomings of early synthetic routes and was ultimately used for the multikilogram scale synthesis of the active pharmaceutical ingredient 1. Further evaluation of the borylation reaction showed useful reactivity with a range of substituted aryl bromides and iodides as coupling partners. These findings represent a practical, efficient, mild, and scalable method for borylation.

POLYCYCLIC ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS

Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.