1215855-70-1Relevant articles and documents
Sterically controlled iodination of arenes via iridium-catalyzed C-H borylation
Partridge, Benjamin M.,Hartwig, John F.
, p. 140 - 143 (2013/03/28)
A mild method to prepare aryl and heteroaryl iodides by sequential C-H borylation and iodination is reported. The regioselectivity of this process is controlled by steric effects on the C-H borylation step and is complementary to existing methods to form aryl iodides. The iodination of boronic esters has potential for the synthesis of radiolabeled aryl iodides, as demonstrated by the concise synthesis of a potential tracer for SPECT imaging.
IODO PRECURSOR FOR A PET IMAGING AGENT OF AMYLOID PLAQUES
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, (2011/09/14)
The invention relates to a precursor for a [18F]-labeled PET tracer for imaging of Alzheimer's Disease, its synthesis and the process for preparing the respective [18F]-labeled PET tracer.
SPECT IMAGING AGENTS OF AMYLOID PLAQUES
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, (2011/10/05)
The invention relates to novel iodine -radiolabeled compounds useful for diagnosing Alzheimer's desease, to respective novel precursors for the synthesis of such compounds, and to the process of manufacturing said imaging agent of the following Formula (I), wherein Q is a six membered aromatic ring, either carbocycle or heterocycle with one N- atom, wherein X1, X2, X3, X4 and X5 are independently selected from N or C, and wherein zero or one of X1 ( X2, X3, X4 or X5 is N and the remaining ones are C; A is either Sn(alkyl)3, I, l-123, l-124, l-125, l-131, Br; wherein alkyl comprises methyl, ethyl, propyl, butyl, pentyl and hexyl, Y is C or N; with the proviso that if X1 ( X2, X3, X4 or X5 has the meaning of N, substitution by A in that position is excluded; or a pharmaceutically acceptable salt thereof.
PIPERAZINE DERIVATIVES FOR BINDING AND IMAGING AMYLOID PLAQUES AND THEIR USE
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Page/Page column 76, (2010/04/06)
The invention relates to compounds of formula (I), their synthesis and their use, in particular for detecting amyloid deposits in a patient.