823197-35-9

Upstream product

• 73406-97-0 5-bromo-2-(piperazin-1-yl)pyridine 
• 100-51-6 benzyl alcohol 
• 100-39-0 benzyl bromide 
• 55717-45-8 6-bromo-pyridin-3-ol 
• 110-85-0 piperazine 
• 84611-43-8 5-(benzyloxy)-2-chloropyridine 
• 41288-96-4 6-chloropyridine-3-ol 
• 630120-99-9 5-(benzyloxy)-2-bromopyridine 

Downstream Products

• 861965-83-5 3-{4-[5-(benzyloxy)pyridin-2-yl]piperazin-1-yl}-1-(4-chlorophenyl)propan-1-one 
• 1134111-49-1 C₂₀H₂₇N₃O₃S 
• 1215855-70-1 tert-butyl N-{2-[4-(5-(benzyloxy)pyridin-2-yl)piperazin-1-yl]-2-oxoethyl}carbamate 
• 1215855-71-2 N-(2-{4-[5-(benzyloxy)pyridin-2-yl]piperazin-1-yl}-2-oxoethyl)-2-fluoropyridine-4-carboxamide 
• 1322094-89-2 1-(2-aminoacetyl)-4-[5-(benzyloxy)pyridin-2-yl]piperazine hydrochloride 
• 1215855-73-4 N-(2-{4-[5-(benzyloxy)pyridin-2-yl]piperazin-1-yl}-2-oxoethyl)-2-bromopyridine-4-carboxamide 
• 1215855-74-5 [18F]-N-(2-{4-[5-(benzyloxy)pyridin-2-yl]piperazin-1-yl}-2-oxoethyl)-2-fluoropyridine-4-carboxamide 
• 1322094-88-1 N-(2-{4-[5-(benzyloxy)pyridin-2-yl]piperazin-1-yl}-2-oxoethyl)-2-iodopyridine-4-carboxamide 
• 1215900-43-8 C₁₈H₂₂N₄O₂ 
• 1416549-11-5 N-{2-[4-(5-(benzyloxy)pyridin-2-yl)piperazin-1-yl]-2-oxoethyl}-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide 
• 287114-37-8 6-(piperazin-1-yl)pyridin-3-ol 
• 1333316-44-1 N-{2-[4-(5-benzyloxy-pyridin-2-yl)-piperazin-1-yl]-2-oxo-ethyl}-3-tributylstannanyl-benzamide 
• 1333316-47-4 N-{2-[4-(5-benzyloxy-pyridin-2-yI)-piperazin-1-yl]-2-oxo-ethyl}-2-iodo-benzamide 
• 1333316-45-2 N-{2-[4-(5-benzyloxy-pyridin-2-yl)-piperazin-1-yl]-2-oxo-ethyl}-4-iodo-benzamide 

Relevant academic research and scientific papers

MALIC ENZYME INHIBITORS

The present invention relates to novel compounds useful as malic enzyme (ME) inhibitors, processes for their preparation and use of these compounds for the therapeutic treatment of disorders mediated by ME such as cancers (e.g. pancreatic ductal adenocarcinoma (PDAC)) in humans.

Novel indole derivative and medicine containing the same (by machine translation)

[A] formation of Amyloid fibrils can be compounds, including therapeutic or prophylactic agent for neurodegenerative disease Amyloid fibrils formation inhibitor compound and of. (I) or its pharmaceutically acceptable compound represented by the formula [a] or a salt or solvate thereof includes the, Amyloid fibrils formation inhibitor. [R1 And R2 Each independently is H, an alkyl group, a cyano group or the like; R3 And R4 Each independently is H, or an alkyl group; R3 And R4 The, joint may form a ring; Ar1 And Ar2 The substituted or unsubstituted heteroaryl group are independently substituted/unsubstituted aryl groups /; X and Y are each independently a single bond, - (=O) - C etc., Z is O or CH2 ; N is an integer of 1 - 3][Drawing] no (by machine translation)

Sterically controlled iodination of arenes via iridium-catalyzed C-H borylation

A mild method to prepare aryl and heteroaryl iodides by sequential C-H borylation and iodination is reported. The regioselectivity of this process is controlled by steric effects on the C-H borylation step and is complementary to existing methods to form aryl iodides. The iodination of boronic esters has potential for the synthesis of radiolabeled aryl iodides, as demonstrated by the concise synthesis of a potential tracer for SPECT imaging.

IODO PRECURSOR FOR A PET IMAGING AGENT OF AMYLOID PLAQUES

The invention relates to a precursor for a [18F]-labeled PET tracer for imaging of Alzheimer's Disease, its synthesis and the process for preparing the respective [18F]-labeled PET tracer.

SPECT IMAGING AGENTS OF AMYLOID PLAQUES

The invention relates to novel iodine -radiolabeled compounds useful for diagnosing Alzheimer's desease, to respective novel precursors for the synthesis of such compounds, and to the process of manufacturing said imaging agent of the following Formula (I), wherein Q is a six membered aromatic ring, either carbocycle or heterocycle with one N- atom, wherein X1, X2, X3, X4 and X5 are independently selected from N or C, and wherein zero or one of X1 ( X2, X3, X4 or X5 is N and the remaining ones are C; A is either Sn(alkyl)3, I, l-123, l-124, l-125, l-131, Br; wherein alkyl comprises methyl, ethyl, propyl, butyl, pentyl and hexyl, Y is C or N; with the proviso that if X1 ( X2, X3, X4 or X5 has the meaning of N, substitution by A in that position is excluded; or a pharmaceutically acceptable salt thereof.

PIPERAZINE DERIVATIVES FOR BINDING AND IMAGING AMYLOID PLAQUES AND THEIR USE

The invention relates to compounds of formula (I), their synthesis and their use, in particular for detecting amyloid deposits in a patient.

COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.

N-{‘4-SUBSTITUTED PIPERAZINE-1-SULFONYLMETHYL!ALKYL}-N-HYDROXYFOMAMIDE COMPOUNDS AS METALLOPROTEINASE INHIBITORS

The invention provides compounds of formula (I): or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein ring B represents a monocyclic aryl ring having six ring atoms or a monocyclic heteroaryl ring having up to six ring atoms and cont

Benzimidazoles that are useful in treating sexual dysfunction

The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction, wherein L is C1-4 alkyl;RA, RB, RC, RD, and RE, are as described in the specification;Z is selected from the group consisting of N, C and CH; andA is aryl and heteroaryl as described in the specification.

Oximes and hydrazones that are useful in treating sexual dysfunction

The present invention relates to oximes and hydrazones of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.