121642-09-9Relevant articles and documents
CuCl/air-mediated oxidative coupling reaction of imidazoheterocycles with N -aryl glycine esters
Jiao, Jing,Zhang, Jun-Rong,Liao, Yan-Yan,Xu, Li,Hu, Maolin,Tang, Ri-Yuan
, p. 30152 - 30159 (2017)
A copper/air mediated oxidative coupling reaction of imidazoheterocycles with N-aryl glycine esters is here described. The reaction proceeded effectively under an air atmosphere without the use of peroxide agents. This simple protocol allows for the preparation of a wide range of imidazoheterocycles with a glycine ester motif, which are of great interest in the field of medicinal chemistry. Interestingly, the coupling of imidazo[1,2-a]pyridine with secondary or tertiary α-amino phenylethanone selectively affords the imidazo[1,2-a]pyridin-3-yl imine or imidazo[1,2-a]pyridin-3-yl diketone in the presence of CuCl and TBHP (tertbutyl hydroperoxide).
Unlocking the direct photocatalytic difluoromethylation of CN bonds
Alemán, José,Garrido-Castro, Alberto F.,Gini, Andrea,Maestro, M. Carmen
supporting information, p. 3769 - 3772 (2020/04/10)
The current study presents a direct CF2H radical addition to CN bonds predicated on the photocatalytic activation of commercially available zinc difluoromethanesulfinate. The mild conditions in place lead to impressive structural diversity, as quinoxalinones and dibenzazepines, among others, are successfully functionalized.
Polarity-Reversed Addition of Enol Ethers to Imines under Visible Light: Redox-Neutral Access to Azide-Containing Amino Acids
Yang, Sen,Zhu, Shuangyu,Lu, Dengfu,Gong, Yuefa
supporting information, p. 8464 - 8468 (2019/10/14)
A three-component and polarity-reversed addition cascade with a glyoxylate-based imine, an enol ether, and TMSN3 was established for the construction of γ-azido amino acids under visible light. This transformation features mild and redox-neutra
