121660-63-7

Basic information

• Product Name: (E)-3-[2-CYCLOPROPYL-4-(4-FLUOROPHENYL)-3-QUINOLYL]-ACROLEIN
• Synonyms: (E)-3-[2-CYCLOPROPYL-4-(4-FLUOROPHENYL)-3-QUINOLYL]-ACROLEIN
• CAS NO: 121660-63-7
• Molecular Formula: C21H16FNO
• Molecular Weight: 317.3562432
• Mol File: 121660-63-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 491.793 °C at 760 mmHg
• Flash Point: 251.228 °C
• Appearance: /
• Density: 1.257 g/cm³
• CAS DataBase Reference: (E)-3-[2-CYCLOPROPYL-4-(4-FLUOROPHENYL)-3-QUINOLYL]-ACROLEIN(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-[2-CYCLOPROPYL-4-(4-FLUOROPHENYL)-3-QUINOLYL]-ACROLEIN(121660-63-7)
• EPA Substance Registry System: (E)-3-[2-CYCLOPROPYL-4-(4-FLUOROPHENYL)-3-QUINOLYL]-ACROLEIN(121660-63-7)

Safety Data

• Hazardous Substances Data: 121660-63-7(Hazardous Substances Data)

Usage

General Description

(E)-3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-acrolein is a chemical compound with a complex structure that includes a cyclopropyl ring, a fluorophenyl group, and a quinolyl moiety attached to an acrolein functional group. (E)-3-[2-CYCLOPROPYL-4-(4-FLUOROPHENYL)-3-QUINOLYL]-ACROLEIN is a member of the acrolein family of compounds, which are known for their reactivity and potential use in organic synthesis. The presence of a double bond in the acrolein group makes this compound prone to undergo addition reactions, making it a valuable precursor in the synthesis of various organic compounds. Additionally, the substitution pattern on the quinolyl and fluorophenyl groups can impact the compound's biological activity and potential pharmacological applications. Further research on this compound's properties and potential uses may reveal its significance in the fields of chemistry, pharmaceuticals, and materials science.

Upstream product

• 113832-57-8 N-ethylidenecyclohexylamine 
• 121660-37-5 2-cyclopropyl-4-(4-fluorophenyl)-3-formylquinoline 
• 7020-80-6 acetaldehyde N-tert-butylimine 
• 6898-74-4 Acetaldehyd-butylimin 
• 1403338-19-1 methyl (2E)-3-[2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-yl]acrylate 
• 121660-43-3 2-cyclopropyl-4-(4-fluoro-phenyl)-6,7-dimethoxy-quinoline-3-carbaldehyde 
• 121659-86-7 methyl 4-(4'-fluorophenyl)-2-cyclopropylquinoline-3-carboxylate 
• 121660-11-5 2-cyclopropyl-4-(4-fluorophenyl)-3-(hydroxymethyl)quinoline 
• 32249-35-7 methyl 3-cyclopropyl-3-oxopropanoate 
• 3800-06-4 2-amino-4'-fluorobenzophenone 
• 391681-95-1 2-cyclopropyl-3-(3-ethoxy-1-hydroxy-2-propenyl)-4-(4-fluorophenyl)quinoline 
• 256431-72-8 (E)-3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-2-propenenitrile 
• 121660-18-2 [2-cyclopropyl-4-(4-fluoro-phenyl)-6,7-dimethoxy-quinolin-3-yl]-methanol 

Downstream Products

• 172336-32-2 (±)-E-3,5-dihydroxy-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-6-heptenoic acid ethyl ester 
• 1403338-25-9 ethyl (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-yl]-3,5-dihydroxy-6-heptenoate, trifluoroacetate salt 
• 1403338-24-8 ethyl (5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-yl]-5-(tert-butyldimethylsilyloxy)-3-oxo-6-heptenoate 
• 1403338-27-1 C₂₉H₃₄FNO₃Si 
• 222306-19-6 (3S,4E)-5-[2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-yl]-3-hydroxypentenoic acid 
• 1403338-23-7 C₃₂H₃₆FN₃O₂Si 
• 1403338-21-5 (3S,4E)-5-[2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-yl]-3-hydroxypentenoic acid (R)-α-methylbenzylamine salt 
• 254452-95-4 ethyl 5(R)-(E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-5-hydroxy-3-oxo-6-heptenoate 
• 380848-30-6 (E)7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-(3S,5S)-dihydroxyhept-6-enic acid ethyl ester 
• 380848-32-8 (E)7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-(3R,5R)-dihydroxyhept-6-enic acid ethyl ester 
• 147511-69-1 (E)-(3S,5S)-7-[2-Cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-3,5-dihydroxy-hept-6-enoic acid 
• 147511-69-1 (E)-(3R,5R)-7-[2-Cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-3,5-dihydroxy-hept-6-enoic acid 
• 254452-90-9 (E)-(S)-5-[2-Cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-3-hydroxy-pent-4-enoic acid methyl ester 
• 254452-94-3 (E)-(R)-5-[2-Cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-3-hydroxy-pent-4-enoic acid methyl ester 

Relevant articles and documents

Synthesis method of (E)-3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinoline]-2-acrolein

The invention relates to a synthesis technology of pharmaceutical chemicals and particularly relates to a synthesis technology of (E)-3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinoline]-2-acrolein. (E)-3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-2-ethyl acrylate is taken as a raw material, and is thoroughly reduced into allyl alcohol through hydroboron, (E)-3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinoline]-2-acrolein is synthesized through DMSO oxidation, reaction conditions are optimized, and the yield of the (E)-3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinoline]-2-acrolein reaches over 95%. The method is simple in operation step, short in reaction period and high in conversion ratio; the required equipment is simple; the method is suitable for industrial massive production; the content of the produced (E)-3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinoline]-2-acrolein is greater than 99%; and the technical requirements of the market on the (E)-3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinoline]-2-acrolein are met.

PROCESS FOR PRODUCING QUINOLINE COMPOUND

By a production method of a quinoline compound represented by the formula (I), which comprises reacting quinolinecarbaldehyde represented by the formula (II) with an imine compound represented by the formula (III) and then subjecting the resulting compoun

PROCESS FOR THE PREPARATION OF QUINOLYLPROPENAL

3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]prop-2-enal is prepared in a high yield by reducing 3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]prop-2-enenitrite with Raney nickel either in the presence of formic acid and 0.25 to 1 part by volume of water per part by volume of formic acid or in the presence of both an amine salt of formic acid and an organic acid.