7020-80-6

Basic information

• Product Name: N-ETHYLIDENE TERT-BUTYLAMINE
• Synonyms: ACETALDEHYDE TERT-BUTYLIMINE;N-ETHYLIDENE TERT-BUTYLAMINE;TIMTEC-BB SBB007648;Ethanimine, N-t-butyl-;N-[(E)-Ethylidene]-2-methyl-2-propanamine;N-Ethylidene t-butylamine;t-Butylethylideneamine;N-ethylidene-2-Methyl-2-propanaMine
• CAS NO: 7020-80-6
• Molecular Formula: C₆H₁₃N
• Molecular Weight: 99.17
• Mol File: 7020-80-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 121.7 °C at 760 mmHg
• Flash Point: 18.4 °C
• Appearance: /
• Density: 0.73 g/cm³
• Vapor Pressure: 17.3mmHg at 25°C
• Refractive Index: 1.403
• CAS DataBase Reference: N-ETHYLIDENE TERT-BUTYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-ETHYLIDENE TERT-BUTYLAMINE(7020-80-6)
• EPA Substance Registry System: N-ETHYLIDENE TERT-BUTYLAMINE(7020-80-6)

Safety Data

• Hazardous Substances Data: 7020-80-6(Hazardous Substances Data)

Usage

Uses

N-Ethylidene-tert-butylamine can be used for general synthetic approach of natural products empowered by potentially biomimetic ring expansion.

InChI:InChI=1/C6H13N/c1-5-7-6(2,3)4/h5H,1-4H3/b7-5+

Upstream product

• 75-07-0 acetaldehyde 
• 75-64-9 tert-butylamine 
• 28705-47-7 N-tert-Butyl-N-vinylcarbamidsaeurechlorid 

Downstream Products

• 6943-47-1 1-tert-butyl-4-methyl-1-aza-1,3-butadiene 
• 120555-67-1 (Z)-β-(4-methoxyphenyl)cinnamic aldehyde 
• 120553-80-2 (E)-β-(4-methoxyphenyl)cinnamic aldehyde 
• 73198-78-4 α-(Trimethylsilyl)-tert-butylacetaldimine 
• 1210-39-5 3,3-diphenyl-2-propenal 
• 72228-10-5 3,3-bis(4-methylphenyl)-2-propenal 
• 120553-11-9 3,3-bis(3-chlorophenyl)-2-propenal 
• 24680-50-0 4-methoxy-trans-cinnamaldehyde 
• 120553-08-4 3,3-bis(4-fluorophenyl)acrylaldehyde 
• 87580-60-7 (E)-3-(4-methoxyphenyl)but-2-enal 
• 120553-85-7 (E)-3-(4-Methoxyphenyl)-2-hexenal 
• 28227-42-1 1,4-di-tert-butyl-1,4-diazabutadiene 
• 13532-81-5 glyoxime-N_.N'-diphenyl ether 
• 495-48-7 azoxybenzene 

Relevant articles and documents

SILYLATED AZULENYL NITRONE SPIN TRAPS AS CHROMOTROPIC SUPEROXIDE DETECTORS

Silylated nitrones and methods of detecting and/or superoxide using silylated nitrones are disclosed herein.

Total synthesis of amiclenomycin, an inhibitor of biotin biosynthesis.

We describe the first synthesis of amiclenomycin, a natural product that has been found to inhibit biotin biosynthesis and, as a consequence, to exhibit antibiotic properties. Structure 1, with a trans relationship between the ring substituents. had previously been proposed for amiclenomycin on the basis of its 1H NMR spectrum. We have prepared the trans and cis isomers 1 and 2 by unequivocal routes and we conclude that the natural product is in fact the cis isomer 2. The properly substituted cyclohexadienyl rings were constructed first. A cycloaddition reaction between 1,2-di(phenylsulfonyl)ethylene and the N-allyloxycarbonyl diene 13, followed by reductive elimination of the phenylsulfinyl groups, gave the cis isomer 15. To obtain the trans isomer, the O-trimethylsilyl diene was used to give the cis hydroxylated Diels-Alder adduct 33, which was transformed into the corresponding trans amino derivative by means of a Mitsunobu reaction. The L-alpha-amino acid functionality was introduced by means of a Strecker reaction on the aldehydes 16 and 42, followed by enzymatic hydrolysis with immobilised pronase.