1217-75-0

Usage

Uses

Used in Pharmaceutical Synthesis:
2,3-Dihydro-1-methyl-2-phenylquinazolin-4(1H)-one is used as a chemical intermediate for the synthesis of pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique structure and properties make it a valuable component in the creation of complex organic molecules.
Used in Drug Development:
As a potential medicinal compound, 2,3-Dihydro-1-methyl-2-phenylquinazolin-4(1H)-one is used in the research and development of drugs for various conditions. Its exploration in this field is still in the early stages, and further studies are needed to understand its full potential and effects on human health.
Used in Organic Chemistry Research:
2,3-Dihydro-1-methyl-2-phenylquinazolin-4(1H)-one is utilized in organic chemistry research to study the properties and reactions of phenylquinazolines. This knowledge can be applied to the design and synthesis of new compounds with potential applications in various industries, including pharmaceuticals, materials science, and agrochemicals.

Upstream product

• 150614-41-8 2,2'-diphenyl-1,1'-dimethyl-3,3'-bis(1,2,3,4-tetrahydroquinazoline)-4,4'-dione 
• 28144-70-9 anthranilic acid amide 
• 100-44-7 benzyl chloride 
• 7505-81-9 2-methylaminobenzamide 
• 100-52-7 benzaldehyde 
• 109632-72-6 2-Benzyl-1-methyl-1,2-dihydro-indazol-3-one 

Downstream Products

• 80477-99-2 3-acetyl-1-methyl-2-phenyl-1,2,3,4-tetrahydroquinazolin-4-one 
• 153076-67-6 1-Methyl-2-phenyl-2,3-dihydro-1H-quinazoline-4-thione 
• 153076-71-2 1-Methyl-4-methylsulfanyl-2-phenyl-1,2-dihydro-quinazoline 

Relevant academic research and scientific papers

Bis-azaheterocycles: Part IV - Thermal and photochemical reactions of some 3,3'-bisquinazoline-4,4'-diones

Pyrolysis of 2,2'-di(2-chlorophenyl)-3,3'-bis(1,2,3,4-tetrahydroquinazoline)-4,4'-dione (1) at 270 deg C gives 2-(2-chlorophenyl)-1,2-dihydro-4(3H)-quinazolinone (4) and 2-(2-chlorophenyl)-4(3H)-quinazolinone (5).Similarly the pyrolysis of 2,2'-diaryl-1,1'-dimethyl-3,3'-bis(1,2,3,4-tetrahydroquinazoline)-4,4'-dione (2a, Ar=phenyl, 2b, Ar=4-methoxyphenyl) yields 2-aryl-1-methyl-1,2-dihydro-4-(3H)-quinazolinone (6a/6b) and 2-aryl-1-methyl-4-(3H)-quinazolinone (7a/7b) along with a dimeric compound 3,3'-diaryl-1,1'-dimethyl-2,2'-bis(1,2,3,4-tetrahydroquinazoline)-4,4'-dione (8a/8b).However, thermolysis of 3,3'-bis(spiro-4'(3'H)-one) (3) at 275 deg C affords 2,5-di(2-aminophenyl)-1,3,4-oxadiazole (9) and 1,2,3,4-tetrahydro-9(10H)acridinone (10).Photolysis of 1, 2a, 2b and 3 furnishes the products 5, 7a, 7b and spiro-4'(3'H)-one (11) respectively.

A simple approach to novel 3-aza-1-dethiacepham analogs

Synthesis of a variety of novel 3-aza-1-dethiacepham analogs (6a-d, 7a-d, 13a-c, 18a, b, 21, 22) via cycloaddition has been described.The reaction of in situ generated ketene and appropriate heterocycles as imine components results in the formation of polycyclic β-lactams.Since thienopyrimidine derivatives have potential biological activity, the main work involves the grafting of β-lactam ring onto these moieties through a simple approach.

ON THE ISOMERIZATION OF DIALKYL INDAZOLONES TO DIHYDRO-QUINAZOLINONES

1,2-dialkyl-3-indazolones isomerize in basic medium to dihydro-4-quinazolinones.These latter, under more drastic conditions, undergo dismutation to 4(3H)-quinazolinones and antranilamides.