109632-72-6Relevant academic research and scientific papers
Synthesis, biological evaluation and chemometric analysis of indazole derivatives. 1,2-Disubstituted 5-nitroindazolinones, new prototypes of antichagasic drug
Vega, María Celeste,Rolón, Miriam,Montero-Torres, Alina,Fonseca-Berzal, Cristina,Escario, José Antonio,Gómez-Barrio, Alicia,Gálvez, Jorge,Marrero-Ponce, Yovani,Arán, Vicente J.
, p. 214 - 227 (2013/02/23)
Chagas disease chemotherapy, currently based on only two drugs, nifurtimox and benznidazole, is far from satisfactory and therefore the development of new antichagasic compounds remains an important goal. On the basis of antichagasic properties previously
Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity
Bruneau,Delvare,Edwards,McMillan
, p. 1028 - 1036 (2007/10/02)
Since the hypothetical mechanisms of hydroperoxydation of arachidonic acid by, respectively, 5-lipoxygenase (5-LPO) and cyclooxygenase (CO) involve a redox cycle, a compound which reduces 5-LPO and CO to their inactive state would give a nonselective inhi
ON THE ISOMERIZATION OF DIALKYL INDAZOLONES TO DIHYDRO-QUINAZOLINONES
Baiocchi, Leandro,Picconi, Giuseppe
, p. 5255 - 5256 (2007/10/02)
1,2-dialkyl-3-indazolones isomerize in basic medium to dihydro-4-quinazolinones.These latter, under more drastic conditions, undergo dismutation to 4(3H)-quinazolinones and antranilamides.
