121748-58-1

Upstream product

• 27374-25-0 [(1-Ethoxycyclopropyl)oxy]trimethylsilane 
• 102-92-1 Cinnamoyl chloride 
• 201230-82-2 carbon monoxide 
• 75-11-6 diiodomethane 
• 1503-99-7 ethyl 3-oxo-5-phenyl-4-pentenoate 
• 110-89-4 piperidine 
• 539-88-8 4-oxopentanoic acid ethyl ester 
• 100-52-7 benzaldehyde 

Downstream Products

• 90147-73-2 ethyl 4-oxo-6-phenylhexanoate 
• 13122-67-3 6-phenyl-4-oxohexanoic acid 
• 121365-22-8 (E)-4-oxo-6-phenylhex-5-enoic acid 

Relevant academic research and scientific papers

Organic catalyst and ligand with rigid spiro[indane-1,2'-pyrrolidine] skeleton, synthesis and application

The invention discloses an organic catalyst and ligand with rigid spiro[indane-1,2'-pyrrolidine] skeleton, synthesis and application. The invention further discloses synthesis methods thereof. The method raw material is cheap and easy to obtain; the react

Preparation and Application of Amino Phosphine Ligands Bearing Spiro[indane-1,2′-pyrrolidine] Backbone

P,Nsp3-bidentate chiral ligands bearing spiro[indane-1,2′-pyrrolidine] backbone were prepared in gram scale for the first time. Pd complexes of these air-stable amino phosphine ligands could catalyze asymmetric allylic substitutions of malonate-, alcohol-, and amine-type nucleophiles in up to 97percent ee and 99percent yield. A crystal structure of [Pd(II)(η3-1,3-diphenylallyl)(ligand)]PF6 indicated possible transition states of the catalytic reactions. These ligands are characteristic of a very rigid backbone, which is simple but highly effective. They rival C2-symmetric bisphosphine, P,Nsp2-bidentate, and P,Nsp3-bidentate ligands in tested allylic substitutions. ?

One-Pot Synthesis of 2,5-Disubstituted Furans through In Situ Formation of Allenes and Enolization Cascade

A one-pot synthesis of 2,5-disubstituted furans from γ-ketoacids is reported. In situ formation of allenoates by action of chloroformate on carboxylic acid following by enolization of ketone affords furan derivatives by cyclization. The reaction was extended to a wide scope of ketoacids and phosphonium salts. This methodology was applied on levulinic acid and derivatives, one of the biosourced platform chemicals.

DICARBONYL DERIVATIVES AND METHODS OF USE

Derivatives of dicarbonyl compounds having antitumor and antibiotic activity which can be used as anticancer agents.

Compounds and inhibitors of phospholipases

The present invention relates generally to amino acid derivatives and to methods of making the same. In particular, the invention relates to compounds bearing a stereochemical identity, that is, the same stereochemistry, with the chiral α-carbon of D-α-amino acids and their use in methods of therapy, including the treatment of inflammatory diseases, and to compositions and enantiomeric mixtures containing them.

Palladium-catalyzed coupling and carbonylative coupling of silyloxy compounds with hypervalent iodonium salts

Arylation and alkenylation of 1-ethoxy-1-trimetylsilyloxycyclopropane with diphenyliodonium tetrafluoroborate and alkenyliodonium tetrafluoroborate were accomplished by slow addition of silyloxycyclopropane to iodonium salts in the presence of Pd(OAc)2 (2 mol %) and DME/H2O (4 : 1) to afford β-substituted ester. Alternatively, carbonylative coupling of silyloxypropane was carried our by slow addition of silyloxypropanes to iodonium salts under CO(1 atm) at room temperature in aqueous medium. The palladium-catalyzed coupling of ketene trimethylsilyl acetals with iodonium sails is also described.

Synthesis of 1,4-Keto Esters and 1,4-Diketones via Palladium-Catalyzed Acylation of Siloxycyclopropanes. Synthetic and Mechanistic Studies

The reaction of a variety of siloxycyclopropanes with acid chlorides in the presence of a catalytic amount of a palladium/phosphine complex gives 1,4-dicarbonyl compounds to good yield. 1-Alkoxy-1-(trialkylsiloxy)-cyclopropanes react with both aromatic and aliphatic acid chlorides in chloroform to give 1,4-keto esters.Synthesis of 1,4-diketones by the acylation of 1-alkyl- or 1-aryl-1-siloxycyclopropanes has been achieved by carrying out the reaction if HMPA under 10-20 atm of carbon monoxide.Kinetic studies and product analysis revealed the unique mechanism of this reaction, which involves rate-determining cleavage of the strained cyclopropane carbon-carbon bond with a coordinatively unsaturated acylpalladium chloride complex.Ab initio calculations of hydroxylated cyclopropane model compounds showed that the unique reactivities of the siloxycyclopropanes may be correlated with the molecular orbital properties of these compounds rather than their ground-state structural properties.

Acid-Catalyzed Transformation of α-Hydroxy-γ-oxo Acetals to γ-Oxo Esters. A Novel Deconjugation of 4-Oxo-2-alkenal Acetals

Under acid catalysis, α-hydroxy-γ-oxo acetals which are readily available from the nitrile oxide cycloaddition route are smoothly convrted into γ-oxo esters.This unusual and high-yield transformation involves rare acid-catalyzed deconjugation of the inter