1503-99-7

Upstream product

• 64-17-5 ethanol 
• 39522-68-4 (E)-1,1-Dichloro-5-phenyl-penta-1,4-dien-3-one 
• 27271-29-0 3-Aethoxy-5-phenyl-2,4-pentadiensaeure-aethylester 
• 13148-05-5 ethyl 3-oxo-4-(triphenylphosphoranylidene)butanoate 
• 100-52-7 benzaldehyde 
• 6082-74-2 4,4-dichloro-3-oxobutyric acid ethyl ester 
• 638-07-3 ethyl (2-chloroaceto)acetate 
• 27271-34-7 (2-ethoxy-3-ethoxycarbonyl-2-propenylidene)triphenylphosphorane 
• 106302-03-8 [3-(ethoxycarbonyl)-2-oxypropyl]triphenylphosphonium chloride 
• 141-97-9 ethyl acetoacetate 
• 76352-65-3 ethyl (E)-2-acetyl-3-oxo-5-phenylpent-4-enoate 
• 64-19-7 acetic acid 
• 4192-77-2 ethyl cinnamate 
• 118171-27-0 N-methyl-3-phenyl-5-(carbethoxymethylene)isoxazolidine 

Downstream Products

• 1210071-83-2 ethyl 1'-acetyl-2-(4-chlorophenyl)-4-hydroxy-2'-oxo-6-phenylspiro[cyclohex[3]ene-1,3'-indoline]-3-carboxylate 
• 1210071-84-3 ethyl 1'-acetyl-2-(4-bromophenyl)-4-hydroxy-2'-oxo-6-phenylspiro[cyclohex[3]ene-1,3'-indoline]-3-carboxylate 
• 1210071-85-4 ethyl 1'-acetyl-4-hydroxy-2-(4-(methoxycarbonyl)phenyl)-2'-oxo-6-phenylspiro[cyclohex[3]ene-1,3'-indoline]-3-carboxylate 
• 1210071-86-5 ethyl 1'-acetyl-2-(3-chlorophenyl)-4-hydroxy-2'-oxo-6-phenylspiro[cyclohex[3]ene-1,3'-indoline]-3-carboxylate 
• 1210071-87-6 ethyl 1'-acetyl-2-(2-chlorophenyl)-4-hydroxy-2'-oxo-6-phenylspiro[cyclohex[3]ene-1,3'-indoline]-3-carboxylate 
• 1210071-88-7 ethyl 1'-acetyl-2-(3,4-dichlorophenyl)-4-hydroxy-2'-oxo-6-phenylspiro[cyclohex[3]ene-1,3'-indoline]-3-carboxylate 
• 1210071-89-8 ethyl 1'-acetyl-4-hydroxy-2-(naphthalen-2-yl)-2'-oxo-6-phenylspiro[cyclohex[3]ene-1,3'-indoline]-3-carboxylate 
• 1210071-91-2 2-benzyl-3-ethyl 1'-acetyl-4-hydroxy-2'-oxo-6-phenylspiro[cyclohex[3]ene-1,3'-indoline]-2,3-dicarboxylate 
• 1210071-92-3 2-tert-butyl-3-ethyl 1'-acetyl-4-hydroxy-2'-oxo-6-phenylspiro[cyclohex[3]ene-1,3'-indoline]-2,3-dicarboxylate 
• 1210071-93-4 ethyl 1'-acetyl-4-hydroxy-2'-oxo-6-phenyl-2-propylspiro[cyclohex[3]ene-1,3'-indoline]-3-carboxylate 
• 1210071-94-5 ethyl 1'-acetyl-4-hydroxy-2-isobutyl-2'-oxo-6-phenylspiro[cyclohex[3]ene-1,3'-indoline]-3-carboxylate 
• 1210072-01-7 ethyl 1'-acetyl-5'-bromo-4-hydroxy-2'-oxo-2,6-diphenylspiro[cyclohex[3]ene-1,3'-indoline]-3-carboxylate 

Relevant academic research and scientific papers

FACILE SYNTHESIS OF β-KETOESTERS BY A COUPLING REACTION OF THE REFORMATSKY REAGENT WITH ACYL CHLORIDES CATALYZED BY A PALLADIUM COMPLEX

β-Ketoesters were obtained in good yields by the reaction of the Reformatsky reagent with acyl chlorides catalyzed by a palladium complex under mild conditions.

Ethyl 4-(diethoxyphosphinyl)-3-oxobutanoate: Selective synthesis of β-keto phosphonates

The selective synthesis of ethyl 4-(diethoxyphosphinyl)-3-oxobutanoate (7) and the utilization of its trimethylsilyl enolether (14) in a tandem desilylation Horner-Wittig condensation is illustrated.

Preparation of γ,δ-unsaturated-β-ketoesters: Lewis acid-catalysed C[sbnd]H insertion of ethyl diazoacetate into α,β-unsaturated aldehydes

The synthesis of γ,δ-unsaturated-β-keto esters was achieved by the Lewis acid-catalysed direct C[sbnd]H insertion of an α-diazoester into various α,β-substituted-unsaturated aldehydes. C[sbnd]H insertion of ethyl diazoacetate into alkyl- and aryl-substituted α,β-unsaturated aldehydes was performed under mild conditions to afford the corresponding γ,δ-unsaturated-β-keto esters in moderate to high yields as a mixture of keto/enol tautomers.

Efficient Synthesis of Functionalized β-Keto Esters and β-Diketones through Regioselective Hydration of Alkynyl Esters and Alkynyl Ketones by Use of a Cationic NHC–AuICatalyst

Regioselective hydration of α-alkynyl esters and ketones by using a cationic NHC–AuIcatalyst results in β-keto esters and β-diketones, respectively. Controlled release of water in acetone by aldol self-condensation under the reaction conditions makes acetone as better solvent than 1,4-dioxane/water for the hydration of α-alkynyl esters having sensitive ester moieties.

Stereoselective synthesis of aryl γ,δ-unsaturated β-hydroxyesters by ketoreductases

The biocatalytic reduction of aryl γ,δ-unsaturated-β- ketoesters was evaluated utilizing 24 different commercially available ketoreductases. In all cases, both (R) and (S)-enantiomers of γ,δ-unsaturated β-hydroxyesters were synthesized by one or more keto

Oxone-mediated oxidative cleavage of β-keto esters and 1,3-diketones to α-keto esters and 1,2-diketones in aqueous medium

A versatile and highly efficient method for the direct synthesis of α-keto esters and 1,2-diketones has been developed. This approach utilizes the oxidative cleavage of a variety of β-keto esters and 1,3-diketones mediated by an Oxone/aluminum trichloride system. The simple one-step oxidation reaction proceeded selectively in aqueous media to afford products in high yields, short reaction times, and environmentally benign conditions.

PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS CONTAINING SAME

The present invention provides pyrazole derivative compounds and pharmaceutically acceptable salts thereof. The compounds of the present invention have an excellent effect of preventing and treating osteoporosis.

Synthesis and anticonvulsant activity of some new series of pyrrole derivatives

A new series of compounds 3a-f were synthesized from condensation method. Newly synthesized compounds were established by IR, 1H NMR, 13C NMR, mass spectral and elemental analysis. Synthesized compounds 3a-f were screened for anticonvulsant activity. The

Cationic vanadium(IV) complexes as efficient catalysts for nazarov cyclizations

Vanadium(IV) species generated in situ from V(salen)Cl2 complexes (1) by reaction with 2 equiv. of AgSbF6 are effective catalysts for Nazarov cyclizations. Thus, dialkenyl ketones bearing α-ester groups are efficiently converted to c

CuSO4-catalyzed diazo decomposition in water: a practical synthesis of β-keto esters

CuSO4 was found to be an efficient catalyst for the diazo decomposition of β-hydroxy α-diazoesters in water. 1,2-H shift occurred efficiently to give β-keto esters in high yields. No O-H bond insertion products were identified.