1217612-37-7

Basic information

• Product Name: (S)-2-(2-METHOXYPHENYL)PYRROLIDINE
• Synonyms: (S)-2-(2-METHOXYPHENYL)PYRROLIDINE;2-((2S)PYRROLIDIN-2-YL)-1-METHOXYBENZENE
• CAS NO: 1217612-37-7
• Molecular Formula: C11H15NO
• Molecular Weight: 177.24
• Mol File: 1217612-37-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 269.4±33.0 °C(Predicted)
• Appearance: /
• Density: 1.024±0.06 g/cm3(Predicted)
• PKA: 10.06±0.10(Predicted)
• CAS DataBase Reference: (S)-2-(2-METHOXYPHENYL)PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(2-METHOXYPHENYL)PYRROLIDINE(1217612-37-7)
• EPA Substance Registry System: (S)-2-(2-METHOXYPHENYL)PYRROLIDINE(1217612-37-7)

Safety Data

• Hazardous Substances Data: 1217612-37-7(Hazardous Substances Data)

Usage

General Description

(S)-2-(2-Methoxyphenyl)pyrrolidine is a chemical compound with the molecular formula C12H17NO and a molecular weight of 191.27 g/mol. It is a chiral compound that exists as a racemic mixture of enantiomers, with one being the (S)-enantiomer. (S)-2-(2-METHOXYPHENYL)PYRROLIDINE is a pyrrolidine derivative with a methoxyphenyl group attached to the second carbon atom. It is commonly used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. Its properties and applications make it a valuable component in the field of medicinal chemistry and drug development.

Upstream product

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Relevant articles and documents

Zinc-Catalyzed Asymmetric Hydrosilylation of Cyclic Imines: Synthesis of Chiral 2-Aryl-Substituted Pyrrolidines as Pharmaceutical Building Blocks

The first successful enantioselective hydrosilylation of cyclic imines promoted by a chiral zinc complex is reported. In situ generated zinc-ProPhenol complex with silane afforded pharmaceutically relevant enantioenriched 2-aryl-substituted pyrrolidines in high yields and with excellent enantioselectivities (up to 99% ee). The synthetic utility of presented methodology is demonstrated in an efficient synthesis of the corresponding chiral cyclic amines, being pharmaceutical drug precursors to the Aticaprant and Larotrectinib. (Figure presented.).

Enantioselective Imine Reduction Catalyzed by Phosphenium Ions

The first use of phosphenium cations in asymmetric catalysis is reported. A diazaphosphenium triflate, prepared in two or three steps on a multigram scale from commercially available materials, catalyzes the hydroboration or hydrosilylation of cyclic imin

Direct α-C-H bond functionalization of unprotected cyclic amines

Cyclic amines are ubiquitous core structures of bioactive natural products and pharmaceutical drugs. Although the site-selective abstraction of C-H bonds is an attractive strategy for preparing valuable functionalized amines from their readily available parent heterocycles, this approach has largely been limited to substrates that require protection of the amine nitrogen atom. In addition, most methods rely on transition metals and are incompatible with the presence of amine N-H bonds. Here we introduce a protecting-group-free approach for the α-functionalization of cyclic secondary amines. An operationally simple one-pot procedure generates products via a process that involves intermolecular hydride transfer to generate an imine intermediate that is subsequently captured by a nucleophile, such as an alkyl or aryl lithium compound. Reactions are regioselective and stereospecific and enable the rapid preparation of bioactive amines, as exemplified by the facile synthesis of anabasine and (-)-solenopsin A.