121783-48-0

Upstream product

• 108-98-5 thiophenol 
• 80-62-6 methacrylic acid methyl ester 
• 72657-23-9 methyl (R)-3-hydroxy-2-methylpropionate 
• 882-33-7 diphenyldisulfane 
• 84341-89-9 (2S)-(+)-2-methyl-3-(toluene-4-sulfonyloxy)propionic acid methyl ester 

Downstream Products

• 121783-49-1 (S)-(+)-2-methyl-3-(phenylthio)propan-1-ol 
• 13012-61-8 2-methyl-3-phenylthio-1-chloropropane 
• 88408-99-5 (2S)-4-(benzyloxy)-1-(phenylsulfonyl)-2-methylbutane 
• 157733-10-3 (S)-3-Methyl-4-phenylsulfanyl-butyronitrile 
• 94807-93-9 (S)-3-methyl-4-phenylthio-1-butanol 
• 187671-48-3 Acetic acid (1R,2S)-1,2-dimethyl-3-phenylsulfanyl-propyl ester 

Relevant academic research and scientific papers

Bifunctional Iminophosphorane Catalyzed Enantioselective Sulfa-Michael Addition to Unactivated α-Substituted Acrylate Esters

The highly enantioselective sulfa-Michael addition of alkyl thiols to unactivated α-substituted acrylate esters catalyzed by a bifunctional iminophosphorane organocatalyst under mild conditions is described. The strong Br?nsted basicity of the iminophosphorane moiety of the catalyst provides the necessary activation of the alkyl thiol pro-nucleophile, while the two tert-leucine residues flanking a central thiourea hydrogen-bond donor facilitate high enantiofacial selectivity in the protonation of the transient enolate intermediate. The reaction is broad in scope with respect to the alkyl thiol, the ester moiety, and the α-substituent of the α,β-unsaturated ester, affords sulfa-Michael adducts in excellent yields (up to >99%) and enantioselectivities (up to 96% ee), and is amenable to decagram scale-up using catalyst loadings as low as 0.05 mol %.

Enantiopure building blocks for the synthesis of 3-methyl-2-alkanols. Diastereoselective methylmetal addition to a chiral 2-methylaldehyde followed by lipase catalysed esterification

The racemic synthetic building block (2R*,3R*)-3-methyl-4- (phenylsulfanyl)butan-2-ol (2R*,3R*)-2 was obtained in a high diastereomeric ratio [95:5, (2R*,3R*)/(2R*,3S*)-ratio] by Lewis acid catalysed dimethylzinc addition to racemic 2-methyl-3- (phenylsul

Convergent synthesis of a key intermediate for hypocholesterolemic agent 1233A, starting from methyl 3-hydroxy-2-methylpropanoate and asymmetrized bis(hydroxymethyl)acetaldehyde (BHYMA*)

Compound 2, which is a known intermediate for the total synthesis of hypocholesterolemic agent 1233A 1, has been synthesized in good overall yield through a convergent approach, employing 3-hydroxy-2-methylpropanoate 6 and BHYMA* 5 as chiral building bloc

PREPARATION OF CHIRAL C5-BUILDING BLOCKS FOR TERPENE SYNTHESIS BY BAKERS' YEAST REDUCTION OF SULFUR-FUNCTIONALIZED PRENYL DERIVATIVES

Enantioselective hydrogenation of several α,β-unsaturated aldehydes and allylic alcohols of sulfur-functionalized prenyl derivatives with bakers' yeast gave bifunctional chiral (S)- and (R)-C5-building blocks for terpene synthesis with high enantiomeric e