121809-01-6Relevant academic research and scientific papers
C2-Symmetric 2,2′-Bipyridine-α,α′-1-adamantyl-diol Ligand: Bulky Iron Complexes in Asymmetric Catalysis
Lauzon, Samuel,Ollevier, Thierry,Schouwey, Lionel
supporting information, p. 1116 - 1120 (2022/02/10)
The synthesis of a chiral 2,2′-bipyridine-α,α′-1-adamantyl-diol ligand was achieved starting from commercially available materials. The bulky ligand was synthesized in three steps in 40% overall yield with stereoselectivities of 98% de and >99.5% ee for the S,S enantiomer. The absolute configuration of and structural insights into a heptacoordinated 2,2′-bipyridine-α,α′-1-Ad-diol/FeII chiral complex were obtained from single-crystal diffraction analyses. The newly synthesized ligand was used in iron-catalyzed asymmetric Mukaiyama aldol, thia-Michael, and Diels-Alder reactions.
Evidence for the importance of π-π attractive interactions in enantioselective Diels-Alder reactions chiral catalysts of type (RO)2TiCl2
Corey,Matsumura
, p. 6289 - 6292 (2007/10/02)
Reaction of diol 4 with Ti(O i-Pr)4 followed by SiCl4 results in formation of the Ti (IV) complex 5 which is an exceptionally effective catalyst for enantioselective Diels-Alder reactions. The origin of the high enantioselectivities
Catalytic enantioselective synthesis of a key intermediate for the synthesis of prostanoids
Corey,Imai,Pikul
, p. 7517 - 7520 (2007/10/02)
A route has been demonstrated for the enantioselective synthesis of prostanoids from achiral starting materials by the use of chiral catalysts of the molecular robot class.
