1219085-06-9

Upstream product

• 1219086-87-9 (Z)-3-(3-chloro-2-fluorophenyl)-2-(4-chloro-2-fluorophenyl)prop-2-enenitrile 
• 1219086-34-6 2-[(E)-(3,3-dimethylbutylidene)amino]acetic acid tert-butyl ester 
• 1219086-88-0 racemic (2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-( 4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carboxylic acid tert-butyl ester 
• 75279-53-7 2-(4-chloro-2-fluoro-phenyl)acetonitrile 
• 85070-48-0 2-fluoro-3-chlorobenzaldehyde 
• 2987-16-8 3,3-dimethylbutyrylaldehyde 

Relevant academic research and scientific papers

Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development

Restoration of p53 activity by inhibition of the p53-MDM2 interaction has been considered an attractive approach for cancer treatment. However, the hydrophobic protein-protein interaction surface represents a significant challenge for the development of s

Substituted Pyrrolidine-2-Carboxamides

There are provided compounds of the formula wherein X, Y, R1, R2, R3, R3, R4, R5, R6 and R7 are as described herein and enantiomers and pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.