1219800-50-6

Basic information

• Product Name: (R)-tert-butyl 4-(2,3-dihydrobenzo[b][1,4]dioxine-2-carbonyl)piperazine-1-carboxylate
• CAS NO: 1219800-50-6
• Molecular Weight: 348.399
• Mol File: 1219800-50-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (R)-tert-butyl 4-(2,3-dihydrobenzo[b][1,4]dioxine-2-carbonyl)piperazine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-tert-butyl 4-(2,3-dihydrobenzo[b][1,4]dioxine-2-carbonyl)piperazine-1-carboxylate(1219800-50-6)
• EPA Substance Registry System: (R)-tert-butyl 4-(2,3-dihydrobenzo[b][1,4]dioxine-2-carbonyl)piperazine-1-carboxylate(1219800-50-6)

Safety Data

• Hazardous Substances Data: 1219800-50-6(Hazardous Substances Data)

Upstream product

• 77948-59-5 2-(chlorocarbonyl)-1,4-benzodioxin 
• 120-80-9 benzene-1,2-diol 
• 67471-01-6 1,4-benzodioxin-2-carboxylic acid 
• 533-58-4 2-Iodophenol 
• 98572-00-0 (S)-2-hydroxymethyl-1,4-benzodioxane 
• 62501-71-7 (S)-2-benzyloxymethyl-2,3-dihydrobenzodioxane 
• 3663-79-4 methyl 2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylate 
• 650597-66-3 (R)-methyl 2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylate 
• 70918-53-5 (+)-(2R)-2,3-dihydro-1,4-benzodioxine-2-carboxylic acid 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 860173-98-4 (R)-N-(1,4-benzodioxan-2-carbonyl)piperazine 
• 104874-86-4 (R)-doxazosin 

Relevant articles and documents

A facile approach to chiral 1,4-benzodioxane toward the syntheses of doxazosin, prosympal, piperoxan, and dibozane

The process describes the concise synthesis of (R/S)-enantiomers of doxazosin, an antidepressant drug and α-adrenergic receptor antagonists like prosympal, piperoxan, and dibozane in practical yields from easily available (R)-2,3-O-cyclohexylidene-d-glyce

Method for synthesizing doxazosin

The invention discloses a method for synthesizing doxazosin and belongs to the technical field of chemical synthesis. According to the method, the doxazosin is synthesized by adopting a synthesis route, represented by formulae shown in the description, different from the conventional technologies, and thus a novel synthesis route is provided for preparing the doxazosin; and the method has the advantages of moderate conditions, simple and convenient steps and high yield, and the doxazosin can be obtained simply and efficiently.

Piperazine compounds

A compound selected from those of formula (I): wherein: R1, R2, R3 and R4, which may be the same or different, each represent an atom or group selected from hydrogen, halogen, alkyl, alkoxy, phenyl and cyano, X represents a bond, an oxygen atom or a group selected from —(CH2)m—, —OCH2— and —NR5—, wherein m represents 1 or 2, and R5 is as defined in the description, Y represents an oxygen atom or a group selected from NR7 and CHR8, wherein R7 and R8 are as defined in the description, Z represents a nitrogen atom or a CH group, n represents 1 or 2, Ak represents an alkylene chain, Ar represents an aryl or heteroaryl group, its optical isomers, and addition salts thereof with a pharmaceutically acceptable acid. Medical products containing the same which are useful in the treatment of conditions requiring a serotonin reuptake inhibitor and/or NK1 antagonist.