1220-92-4

Upstream product

• 88-73-3 2-Chloronitrobenzene 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 29787-22-2 4'-Tolyl-2-nitrophenylsulfoxid 
• 20912-17-8 2-(4-methylphenylsulfanyl)nitrobenzene 
• 536-57-2 p-toluene sulfinic acid 
• 609-73-4 o-nitroiodobenzene 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 552-16-9 ortho-nitrobenzoic acid 
• 5720-05-8 4-methylphenylboronic acid 
• 15898-45-0 sodium 2-nitrobenzenesulfinate 
• 1493-27-2 ortho-nitrofluorobenzene 
• 528-29-0 1,2-Dinitrobenzene 

Downstream Products

• 15822-77-2 1-(2-nitrophenyl)piperidine 
• 1213-33-8 o-aminophenyl p-tolyl sulfone 
• 61174-45-6 2-Azidophenyl-4-tolylsulfon 
• 1216-90-6 2-p-Toluolsulfonyl-phenylhydrazin 
• 1236-18-6 2-p-Toluolsulfonyl-benzolazocarbonsaeure-ethylester 

Relevant academic research and scientific papers

Nano copper catalyzed synthesis of symmetrical/unsymmetrical sulfones from aryl/alkyl halides and p-toluenesulfonylmethylisocyanide: TosMIC as a tosyl source

A magnetically induced nano copper-catalyzed efficient and mild route for the synthesis of diaryl and alkyl/aryl sulfones from aryl/alkyl halides and tosylmethyl isocyanide (TosMIC) has been developed. A variety of aryl and alkyl sulfones have been obtained in very good to excellent yields. Sulfones containing molecules have medicinal relevance as they are known to possess various activities such as antifungal, anti-HIV, antitumor, and anticancer. Herein, a magnetically induced nano copper-catalyzed efficient and mild route for the synthesis of biaryl and alkyl/aryl sulfones from aryl/alkyl halides and tosylmethyl isocyanide (TosMIC) has been developed. A variety of aryl and alkyl sulfones have been obtained in very good to excellent yields. In this newly developed protocol TosMIC acts as sulfonyl source. The catalyst can magnetically be recovered and recycled five times without significant loss in activity.

TosMIC and its derivatives as versatile sulfonylating agents for the synthesis of p-toluenesulfonylarenes from aryl halides and arylboronic acids

An efficient copper(II) catalyzed sulfonyation of aryl halides has been achieved using TosMIC (p-toluenesulfonylmethyl isocyanide) as a sulfonylating agent. This newly developed sulfonylation approach provides an easy access for the synthesis of diaryl sulfones from aryl bromides, iodides and boronic acids with TosMIC under neutral conditions. This method is useful for the sulfonylation of aryl boronic acids under similar conditions. This is the first report on the sulfonylation of aryl bromides, iodides and boronic acids using TosMIC.

An efficient heterogeneous copper fluorapatite (CuFAP)-catalysed oxidative synthesis of diaryl sulfone under mild ligand- and base-free conditions

A simple, eco-friendly and efficient method for the synthesis of unsymmetrical diaryl sulfones using heterogeneous copper fluorapatite (CuFAP)-catalysed coupling of aryl sulfonic acid and phenyl boronic acid has been developed with good to excellent yields without use of any ligand, base or co-catalyst. Broad substrate scope and gram scale operations are the important features of this method.

Silver-promoted decarboxylative sulfonylation of aromatic carboxylic acids with sodium sulfinates

A novel and efficient synthesis of sulfones was developed via a silver-promoted decarboxylative sulfonylation reaction between aromatic carboxylic acids and sodium sulfinates for the first time. The approach features operational simplicity and good functional group compatibility and uses readily available starting materials. Furthermore, mechanistic studies reveal that the decarboxylative sulfonylation reaction is likely to proceed via a radical mechanism.

ARYL-SULFONAMIDE AND ARYL-SULFONE DERIVATIVES AS TRPML MODULATORS

The new arylsulfonamide and arylsulfone derivatives are modulators of TRPML and are useful in treating disorders related to TRPML activities and lysosome functions such as acid-related disorders and cancer.

A mild and efficient synthesis of aryl sulfones from aryl chlorides and sulfinic acid salts using microwave heating

The CuCl-catalyzed coupling of aryl chlorides and sulfinic acid salts provides a simple and extremely efficient route to unsymmetrical aryl sulfones in high to excellent yields under microwave irradiation within 3-30 minutes. Georg Thieme Verlag Stuttgart · New York.

Aryl and heteroaryl compounds having anti-retrovirus activity

The present invention relates to a method of treating a retrovirus utilizing a compound of the formula The present invention also relates to pharmaceutical compositions in which the active ingredient has a compound of formula I.