1220126-45-3

Upstream product

• 252058-33-6 2-(4-methoxyphenyl)propanal 
• 78-94-4 methyl vinyl ketone 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 1643566-27-1 4'-methoxy-1-methyl-[1,1'-biphenyl]-4(1H)-one 
• 99432-86-7 4-methyl-4-(4-methoxyphenyl)-cyclohex-2-en-1-one 
• 191725-57-2 1-methoxy-4-(1-methoxyprop-1-en-2-yl)benzene 

Relevant academic research and scientific papers

Nickel-Catalyzed Desymmetric Hydrogenation of Cyclohexadienones: An Efficient Approach to All-Carbon Quaternary Stereocenters

Nickel-catalyzed desymmetric hydrogenation has been achieved. With the Ni(OTf)2/(S,S)-Ph-BPE system, a series of ?,?-disubstituted cyclohexadienones were transformed to the corresponding cyclohexenones with a chiral all-carbon quaternary center at the γposition in high yields (92-98%) and excellent enantioselectivities (92%-99% ee). This catalytic system can also tolerate the desymmetric reaction of spirocarbocyclic cyclohexadienones to produce the corresponding cyclohexenones bearing a chiral spiro quaternary carbon with high yields (94%-98%) and ee values (96%-99% ee). Furthermore, this methodology provides an efficient and concise synthetic route to the intermediate of natural products cannabispirenones A and B.

Asymmetric Induction at Remote Quaternary Centers of Cyclohexadienones by Rhodium-Catalyzed Conjugate Hydrosilylation

The enantioselective desymmetrizing conjugate hydrosilylation of prochiral differently γ,γ-disubstituted cyclohexadienone derivatives 2 to furnish the corresponding cyclohexenones 4 with a remote chiral all-carbon quaternary center at the γ position is de

A new powerful strategy for the organocatalytic asymmetric construction of a quaternary carbon stereogenic center

(Figure Presented) A new method for chiral diamine-catalyzed Robinson-type annulation was developed to construct cyclohexenone derivatives bearing a quaternary carbon stereogenic center at the 4-position in high enantiomeric excess. This method was successfully applied to the short synthesis of (+)-sporochnol A.