122159-58-4

Basic information

• Product Name: 3-(3-TRIFLUOROMETHYL-PHENYL)-THIOPHENE
• Synonyms: AKOS BAR-1395;3-(3-TRIFLUOROMETHYL-PHENYL)-THIOPHENE
• CAS NO: 122159-58-4
• Molecular Formula: C11H7F3S
• Molecular Weight: 228.23
• Mol File: 122159-58-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(3-TRIFLUOROMETHYL-PHENYL)-THIOPHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-TRIFLUOROMETHYL-PHENYL)-THIOPHENE(122159-58-4)
• EPA Substance Registry System: 3-(3-TRIFLUOROMETHYL-PHENYL)-THIOPHENE(122159-58-4)

Safety Data

• Hazardous Substances Data: 122159-58-4(Hazardous Substances Data)

Upstream product

• 188290-36-0 thiophene 
• 455-14-1 4-trifluoromethylphenylamine 
• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 
• 6165-69-1 Thien-3-ylboronic acid 
• 10486-61-0 3-thienyl iodide 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 872-31-1 3-Bromothiophene 

Relevant articles and documents

Redox-Divergent Construction of (Dihydro)thiophenes with DMSO

Thiophene-based rings are one of the most widely used building blocks for the synthesis of sulfur-containing molecules. Inspired by the redox diversity of these features in nature, we demonstrate herein a redox-divergent construction of dihydrothiophenes, thiophenes, and bromothiophenes from the respective readily available allylic alcohols, dimethyl sulfoxide (DMSO), and HBr. The redox-divergent selectivity could be manipulated mainly by controlling the dosage of DMSO and HBr. Mechanistic studies suggest that DMSO simultaneously acts as an oxidant and a sulfur donor. The synthetic potentials of the products as platform molecules were also demonstrated by various derivatizations, including the preparation of bioactive and functional molecules.

AgONO-Assisted Direct C-H Arylation of Heteroarenes with Anilines

A novel copper-catalyzed C-H arylation of heteroarenes with anilines by an in situ diazonium reaction is established by using silver nitrite (AgONO) as an unconventional nitrosating reagent under acid-free conditions. It provides a complementary approach for the C-H arylation of electron-rich heteroarenes with aromatic amines affording a variety of heterobiaryls in moderate to good yields.

PPAR active compounds

Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.