122243-30-5

Basic information

• Product Name: 2-(3-bromophenyl)-1,1,1-trifluoropropan-2-ol
• Synonyms: 2-(3-bromophenyl)-1,1,1-trifluoropropan-2-ol
• CAS NO: 122243-30-5
• Molecular Weight: 269.061
• Mol File: 122243-30-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(3-bromophenyl)-1,1,1-trifluoropropan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-bromophenyl)-1,1,1-trifluoropropan-2-ol(122243-30-5)
• EPA Substance Registry System: 2-(3-bromophenyl)-1,1,1-trifluoropropan-2-ol(122243-30-5)

Safety Data

• Hazardous Substances Data: 122243-30-5(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Uses

Intermediate in the synthesis of pharmaceuticals and agrochemicals

Derivative of

Fluorine and bromine

Contains

A hydroxyl group, making it an alcohol

Use in organic synthesis

Building block for creating more complex chemical compounds

Unique properties

Presence of bromine and fluorine

Applications

Various industries, including chemical reactions

Upstream product

• 421-50-1 1,1,1-trifluoro-2-propanone 
• 108-36-1 1,3-dibromobenzene 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 2142-63-4 1-(3-Bromophenyl)ethanone 
• 111762-31-3 3-bromophenyl magnesium bromide 
• 917-64-6 methyl magnesium iodide 
• 655-26-5 m-bromotrifluoroacetone 

Downstream Products

• 1320208-49-8 C₉H₉F₃OS 
• 1320208-50-1 C₉H₈ClF₃O₃S 
• 1448318-85-1 2-(3-bromophenyl)-1,1,1-trifluoropropan-2-yl-methanesulphonate 
• 1448318-87-3 3-(1,1,1-trifluoro-2-methylpropan-2-yl)benzoic acid 
• 1448318-86-2 1-bromo-3-(1,1,1-trifluoro-2-methylpropan-2-yl)benzene 
• 122243-15-6 3-Nitro-benzenesulfonic acid 1-(3-cyano-phenyl)-2,2,2-trifluoro-1-methyl-ethyl ester 
• 122243-13-4 3-Nitro-benzenesulfonic acid 1-(3-bromo-phenyl)-2,2,2-trifluoro-1-methyl-ethyl ester 
• 122242-97-1 Toluene-4-sulfonic acid 1-(3-bromo-phenyl)-2,2,2-trifluoro-1-methyl-ethyl ester 
• 122243-31-6 3-(2,2,2-Trifluoro-1-hydroxy-1-methyl-ethyl)-benzonitrile 

Relevant articles and documents

COMPOUNDS AND USES THEREOF

The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N → S (nN → σ? S-X) Interaction for Conformational Constraint

The HTS-based discovery and structure-guided optimization of a novel series of GKRP-selective GK-GKRP disrupters are revealed. Diarylmethanesulfonamide hit 6 (hGK-hGKRP IC50 = 1.2 μM) was optimized to lead compound 32 (AMG-0696; hGK-hGKRP IC50 = 0.0038 μM). A stabilizing interaction between a nitrogen atom lone pair and an aromatic sulfur system (nN → σ?S-X) in 32 was exploited to conformationally constrain a biaryl linkage and allow contact with key residues in GKRP. Lead compound 32 was shown to induce GK translocation from the nucleus to the cytoplasm in rats (IHC score = 0; 10 mg/kg po, 6 h) and blood glucose reduction in mice (POC = -45%; 100 mg/kg po, 3 h). X-ray analyses of 32 and several precursors bound to GKRP were also obtained. This novel disrupter of GK-GKRP binding enables further exploration of GKRP as a potential therapeutic target for type II diabetes and highlights the value of exploiting unconventional nonbonded interactions in drug design.

Substituent effects. XIX. Solvolysis of 1-aryl-1-(trifluoromethyl)ethyl tosylates

-