129122-41-4Relevant academic research and scientific papers
PYRIDINE ANCHORS FOR HMG-COA REDUCTASE INHIBITORS
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, (2008/06/13)
Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have a quinoline or a pyridine anchor attached by means of a linker to a binding domain sidechain, which compounds inhibit the e
7-substituted derivatives of 3,5-dihydroxyhept-6-ynoic acids and corresponding lactones and their use as hypercholeserolemics
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, (2008/06/13)
7-Substituted 3,5-dihydroxyhept-6-ynoic acids and the derivatives thereof of the formula I STR1 as well as the corresponding lactones of the formula II STR2 in which R and R° have the specified meanings, a process for the preparation of these compounds, t
Phosphorus-Containing Inhibitors of HMG-CoA Reductase. 2. Synthesis and Biological Activites of a Series of Substituted Pyrydynes Containing a Hydroxyphosphinyl Moiety
Robl, Jeffrey A.,Duncan, Laurelee A.,Pluscec, Jelka,Karanevsky, Donald S.,Gordon, Eric M.,et al.
, p. 2804 - 2815 (2007/10/02)
A series of 2,3,4,(5),6-substituted pyridines containing a hydroxyphosphinyl functionality have been prepared and were evaluated for their ability to inhibit the enzyme HMG-CoA reductase.Systematic substitution of both R1-R4 and X-Y
