122263-03-0

Basic information

• Product Name: 2-Acetyloxy-1(2,4-difluorophenyl)ethanone
• Synonyms: 2-Acetyloxy-1-(2,4-difluorophenyl)ethanone;1-fluoro-2-(4-fluorophenyl)-2-oxoethyl acetate;2-Acetoxy-1-(2,4-difluorophenyl)ethanone;[2-(2,4-difluorophenyl)-2-oxoethyl] acetate
• CAS NO: 122263-03-0
• Molecular Formula: C₁₀H₈F₂O₃
• Molecular Weight: 214.17
• EINECS: 1312995-182-4
• Product Categories: Aromatics;Miscellaneous Reagents
• Mol File: 122263-03-0.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Acetyloxy-1(2,4-difluorophenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Acetyloxy-1(2,4-difluorophenyl)ethanone(122263-03-0)
• EPA Substance Registry System: 2-Acetyloxy-1(2,4-difluorophenyl)ethanone(122263-03-0)

Safety Data

• Hazardous Substances Data: 122263-03-0(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

Uses

Intermediate in the production of antifungal agents.

Upstream product

• 102429-07-2 2-bromo-2',4'-difluoroacetophenone 
• 127-09-3 sodium acetate 
• 51336-94-8 2-chloro-1-(2,4-dichlorophenyl)ethanone 

Downstream Products

• 1202852-66-1 2-(2,4-difluorophenyl)but-3-ene-1,2-diol 
• 182482-28-6 2-(tert-Butyl-dimethyl-silanyloxy)-1-(2,4-difluoro-phenyl)-ethanone 
• 182482-31-1 1-(2,4-Difluoro-phenyl)-2-(tetrahydro-pyran-2-yloxy)-ethanone 
• 145240-42-2 1-(2,4-difluorophenyl)-2-hydroxyethanone 

Relevant articles and documents

Enzyme-catalysed approach to the preparation of triazole antifungals: synthesis of (-)-genaconazole

The work describes a new enzyme-mediated approach to optically active epoxide (2R,3S)-6, which is an important key intermediate in the preparation of single enantiomers of chiral azole antifungals. The conversion of (2R,3S)-6 into (-)-genaconazole is reported as an example of its synthetic relevance.

Tetrahydrofuran antifungals

A compound represented by the formula I STR1 wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R1 is a straight or branched chain (C3 to C8) alkyl group substituted by one or two amino acid ester groups (e.g., an amino acid ester group convertible in vivo into a hydroxy group) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.

Hydroxy-substituted antifungals

A compound represented by the formula I STR1 wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R1 is a straight or branched chain (C3 to C8) alkyl group substituted by one or two hydroxy moieties, an ether or ester thereof (e.g., a polyether ester, heterocyclic ester amino acid ester or phosphate ester) thereof and the carbon with the asterisk (*) has the R or S absolute configuration or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.