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19314-92-2

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19314-92-2 Usage

Uses

6,8-Dihydroxy-3-methylisochroman-1-one is an intermediate used in the total synthesis of 6,8-dimethoxy-3-methylisocoumarin, a fungal metabolite precursor.

Check Digit Verification of cas no

The CAS Registry Mumber 19314-92-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,3,1 and 4 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 19314-92:
(7*1)+(6*9)+(5*3)+(4*1)+(3*4)+(2*9)+(1*2)=112
112 % 10 = 2
So 19314-92-2 is a valid CAS Registry Number.

19314-92-2Related news

Free CoA as activator of 6-Hydroxymellein (cas 19314-92-2) synthase, a multifunctional polyketide biosynthetic enzyme in carrot08/11/2019

The activity of 6-hydroxymellein (6HM) synthase, a multifunctional polyketide biosynthetic enzyme in carrot, was appreciably inhibited in the presence of ATP: citrate lyase, a CoA-scavenging enzyme. Catalytic rate of the synthase markedly decreased when deuterium-labeled NADPH was employed in th...detailed

Activation of acyl condensation reaction of monomeric 6-Hydroxymellein (cas 19314-92-2) synthase, a multifunctional polyketide biosynthetic enzyme, by free coenzyme A08/10/2019

6-Hydroxymellein (6HM) synthase is a multifunctional polyketide enzyme induced in carrot cells, whose fully active homodimer catalyzes condensation of acyl-CoAs and the NADPH-dependent ketoreduction of the enzyme-bound intermediate. 6HM-forming activity of the synthase was markedly decreased whe...detailed

Role of reducing co-factors in catalytic reactions of 6-Hydroxymellein (cas 19314-92-2) synthase, a multifunctional polyketide biosynthetic enzyme in carrot cells08/09/2019

6-Hydroxymellein (6HM) synthase, a multifunctional polyketide biosynthetic enzyme in carrot cells, is capable of catalyzing the acyl-CoA condensation and the ketoreduction in the presence of the nucleotide reducing co-factors. Although free CoA at high concentrations functioned as the activator ...detailed

Transacylase-like structure and its role in substrate channeling of 6-Hydroxymellein (cas 19314-92-2) synthase, a multifunctional polyketide biosynthetic enzyme in carrot cell extracts08/08/2019

6-Hydroxymellein synthase, a multifunctional polyketide biosynthetic enzyme of carrot, lost the binding ability toward its co-substrates, acetyl- and malonyl-CoAs, by the treatment with the blocking reagents for serine-OH. In contrast, the enzyme retained the binding ability even when the two SH...detailed

Unusual arrangement of catalytic domains in head-to-tail associated homodimer of 6-Hydroxymellein (cas 19314-92-2) synthase, a multifunctional polyketide biosynthetic enzyme08/07/2019

6-Hydroxymellein synthase, a multifunctional polyketide synthetic enzyme in carrot, is organized as a homodimer, and the activity of the synthase was appreciably inhibited upon the specific alkylation of cysteine- and cysteamine-SHs at the reaction center with iodoacetoamide and chloroacetyl-CoA...detailed

6-Hydroxymellein (cas 19314-92-2) synthetase as a multifunctional enzyme complex in elicitor-treated carrot root extract08/06/2019

Synthetic activity of a polyketide compound 6-hydroxymellein was induced in elicitor-treated carrot root tissues. The activity was significantly inhibited by an antiserum raised against the acyl carrier protein (ACP) of fatty acid synthetase, suggesting that the enzyme(s) for 6-hydroxymellein sy...detailed

Toxicity of 6-methoxymellein and 6-Hydroxymellein (cas 19314-92-2) to the producing carrot cells08/05/2019

6-Methoxymellein (6-MM) is the carrot phytoalexin and 6-hydroxymellein (6-HM) its immediate biosynthetic precursor. 6-MM is more toxic than 6-HM to the producing carrot cells, as demonstrated by the differential toxicity of these two dihydroisocoumarins to either colony forming units in solid me...detailed

Dimer as the active form of a polyketide biosynthetic enzyme 6-Hydroxymellein (cas 19314-92-2) synthase08/04/2019

Activity of 6-hydroxymellein synthase, an inducible polyketide biosynthetic enzyme in carrot cell extracts, was appreciably inhibited in the presence of molar levels of NaCl or (NH4)2SO4. However, the salt-induced inhibition of the synthase activity was reversible, and was almost fully restored ...detailed

Interaction between cerulenin and 6-Hydroxymellein (cas 19314-92-2) synthase in carrot cell extracts08/03/2019

Activity of 6-hydroxymellein synthase, an induced polyketide synthetic enzyme in carrot cell extract, was not inhibited by cerulenin which is known as a potent inhibitor for fatty acid synthases and biosynthetic enzymes of various polyketide compounds. However, when 6-hydroxymellein synthase was...detailed

Induction of 6-methoxymellein 6-Hydroxymellein (cas 19314-92-2) production in carrot cells08/02/2019

6-Methoxymellein, a phytoalexin of carrot, and 6-hydroxymellein, its presumed biosynthetic precursor, were isolated from carrot root slices infected with Sclerotium rolfsii and Fusarium solani. Elicitation of both 6-methoxymellein and 6-hydroxymellein synthesis was achieved also in carrot cell s...detailed

19314-92-2Relevant articles and documents

Direct isocoumarin synthesis through LDA-promoted addition of acetaldehyde on orsellinate. An abrupt synthesis of 6-hydroxymellein, a fungal phytotoxin

Barbier,Devys

, p. 2757 - 2762 (2007/10/02)

The LDA-promoted addition of acetaldehyde on orsellinate gives (±) 6-hydroxymellein, a fungal phytotoxin, with a 51% yield.

Synthesis of Chlorinated Isocoumarin Derivatives

Henderson, Graeme B.,Hill, Robert A.

, p. 1111 - 1116 (2007/10/02)

Syhtheses of 5-chloro-, 7-chloro-, and 5,7-dichloro-isocoumarin derivatives, including the fungal metabolites 5-chloro-3,4-dihydro-8-hydroxy-6-methoxy-3-methylisocoumarin (3), 7-chloro-3,4-dihydro-8-hydroxy-6-methoxy-3-methylisocoumarin (2), and 5,7-dichl

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