122488-36-2

Upstream product

• 52311-59-8 4-chloro-2-nitrobenzyl bromide 
• 122488-79-3 6-Chloro-9-(4-chloro-2-nitro-benzyl)-2-trifluoromethyl-9H-purine 
• 2268-14-6 1,9-dihydro-2-(trifluoromethyl)-6H-purin-6-one 
• 1998-63-6 6-chloro-2-(trifluoromethyl)-9H-purine 
• 22996-18-5 (4-chloro-2-nitrophenyl)methanol 
• 122488-35-1 [9-(4-Chloro-2-nitro-benzyl)-2-trifluoromethyl-9H-purin-6-yl]-dimethyl-amine 

Relevant academic research and scientific papers

Synthesis and antirhinovirus activity of 6-(dimethylamino)-2-(trifluoromethyl)-9-(substituted benzyl)-9H-purines

A series of 6-(dimethylamino)-2-(trifluoromethyl)-9-(substituted benzyl)purines was synthesized and tested for antirhinovirus activity. Most of the compounds were synthesized by alkylation of 6-chloro-2-(trifluoromethyl)-9H-purine with the appropriate benzyl halide followed by displacement of the chloro group with dimethylamine. Alternatively, 6-(dimethylamino)-2-(trifluoromethyl)purine was alkylated with the appropriate benzyl halide. Although several different aryl substituents provided compounds with IC50's = 0.03 μM against rhinovirus serotype 1B, no congener was significantly more active than the parent 2. Twenty-three compounds were tested against 18 other serotypes, but none exhibited a uniform profile of activity.

Exploration of phenyl-spaced 2-amino-(5-9)-phosphonoalkanoic acids as competitive N-methyl-D-aspartic acid antagonists

To investigate the preferred spatial relationship of the distal phosphonic acid to the α-amino acid group of the established competitive N-methyl-D-aspartic acid (NMDA) antagonists APH (1) and APV (2), we have prepared a series of ortho-, meta-, and para-