1224887-80-2

Usage

Chemical structure

Contains a benzene ring and a pyridine ring A nitrile derivative with a fused aromatic structure featuring a six-membered benzene ring and a six-membered pyridine ring.

Chlorine content

Two chlorine atoms The presence of two chlorine atoms in the 2,5-positions of the pyridine ring provides additional reactivity and properties to the compound.

Nitrile group

Cyano group (-CN) A functional group consisting of a carbon atom triple-bonded to a nitrogen atom, contributing to the compound's reactivity and potential applications.

Intermediate in synthesis

Used in the production of pharmaceuticals and agrochemicals 2-[(2,5-dichloro-4-pyridinyl)amino]benzonitrile serves as a crucial building block for creating various drugs and pesticides.

Potential applications

Organic synthesis and materials science The compound may be utilized in the development of new organic compounds and advanced materials due to its unique structure and properties.

Hazards and handling

Careful handling required 2-[(2,5-dichloro-4-pyridinyl)amino]benzonitrile may pose risks to human health and the environment if not used or disposed of properly, so appropriate safety precautions should be taken.

Upstream product

• 1885-29-6 anthranilic acid nitrile 
• 796851-03-1 2,5-dichloro-4-iodo-pyridine 
• 55934-01-5 2,3,5-trichloropyridine 

Downstream Products

• 1224887-82-4 2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)a mino]benzonitrile 
• 1350327-43-3 C₁₉H₁₆ClN₃O₃ 
• 1224887-83-5 2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)amino]benzoic acid 
• 1224887-10-8 2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)amino]-N(methyloxy)benzamide 
• 1224887-99-3 2-({5-chloro-2-[(1-ethyl-3-methyl-1H-pyrazol-5-yl)amino]-4-pyridinyl}amino)benzonitrile 

Relevant academic research and scientific papers

METHOD OF ADMINISTRATION AND TREATMENT

This invention relates to a method of treating cancer in a human in need thereof, comprising determining the presence or absence of a detectable amount of a gene product of the Neurofibromin-2 (NF2) gene in a sample from said human, and administering to said human an effective amount of a focal adhesion kinase (FAK) inhibitor, or a pharmaceutically acceptable salt thereof, if no gene product or no isoform 1 gene product is detected. This invention also relates to a method of treating cancer in a human in need thereof, comprising determining the presence or absence of a detectable amount of a functional isoform 1 protein of the NF2 gene, or a functional fragment thereof, in a sample from said human, and administering to said human an effective amount of a focal adhesion kinase (FAK) inhibitor, or a pharmaceutically acceptable salt thereof, if no gene product or no isoform 1 gene product is detected.

Synthesis and SAR of 2-Phenoxypyridines as novel c-Jun N-terminal kinase inhibitors

The design and synthesis of a novel series of c-jun N-terminal kinase (JNK3) inhibitors is described. The development and optimization of the 2-phenoxypyridine series was carried out from an earlier pyrimidine series of JNK1 inhibitors. Through the optimization of the scaffold 2, several potent compounds with good in vivo profiles were discovered.

PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK

The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.