1225463-77-3

Basic information

• Product Name: tert-butyl 4-(5-phenyl-1,3,4-oxadiazol-2-yl)piperazine-1-carboxylate
• Synonyms: tert-butyl 4-(5-phenyl-1,3,4-oxadiazol-2-yl)piperazine-1-carboxylate
• CAS NO: 1225463-77-3
• Molecular Weight: 330.387
• Mol File: 1225463-77-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-(5-phenyl-1,3,4-oxadiazol-2-yl)piperazine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(5-phenyl-1,3,4-oxadiazol-2-yl)piperazine-1-carboxylate(1225463-77-3)
• EPA Substance Registry System: tert-butyl 4-(5-phenyl-1,3,4-oxadiazol-2-yl)piperazine-1-carboxylate(1225463-77-3)

Safety Data

• Hazardous Substances Data: 1225463-77-3(Hazardous Substances Data)

Upstream product

• 825-56-9 2-phenyl-1,3,4-oxadiazole 
• 1193466-76-0 tert-butyl 4-chloropiperazine-1-carboxylate 
• 51039-53-3 2-phenyl-5-bromo-1,3,4-oxadiazole 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 93-89-0 benzoic acid ethyl ester 
• 65-85-0 benzoic acid 
• 613-94-5 benzoic acid hydrazide 
• 77278-40-1 tert-butyl 4-(benzoyloxy)piperazine-1-carboxylate 

Relevant articles and documents

Copper-Catalyzed Electrophilic Amination of Benzoxazoles via Magnesation

One-pot synthesis of 2-aminobenzoxazoles through copper-catalyzed electrophilic amination of benzoxazoles with O-benzoyl hydroxylamines is described. The direct magnesation of benzoxazoles with the readily available iPrMgCl generated benzoxazolylmagnesium reagents in situ and these reagents were treated with electrophilic amines in the presence of 10 mol-% Cu(OAc)2 and ZnCl2 under mild reaction conditions. A variety of 2-aminobenzoxazoles were obtained in good to excellent yields.

A new entry of amination reagents for heteroaromatic C-H bonds: Copper-catalyzed direct amination of azoles with chloroamines at room temperature

Chloroamine serves as an efficient amination reagent to the heteroaromatic C-H bond of azole under copper catalysis even at room temperature. This catalysis enables a rapid and concise construction of aminoazoles of great interest in biological and medicinal chemistry.