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Upstream product

• 825-56-9 2-phenyl-1,3,4-oxadiazole 
• 77278-40-1 tert-butyl 4-(benzoyloxy)piperazine-1-carboxylate 
• 613-94-5 benzoic acid hydrazide 
• 65-85-0 benzoic acid 
• 93-89-0 benzoic acid ethyl ester 
• 51039-53-3 2-phenyl-5-bromo-1,3,4-oxadiazole 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 1193466-76-0 tert-butyl 4-chloropiperazine-1-carboxylate 

Relevant academic research and scientific papers

Copper-Catalyzed Electrophilic Amination of Benzoxazoles via Magnesation

One-pot synthesis of 2-aminobenzoxazoles through copper-catalyzed electrophilic amination of benzoxazoles with O-benzoyl hydroxylamines is described. The direct magnesation of benzoxazoles with the readily available iPrMgCl generated benzoxazolylmagnesium reagents in situ and these reagents were treated with electrophilic amines in the presence of 10 mol-% Cu(OAc)2 and ZnCl2 under mild reaction conditions. A variety of 2-aminobenzoxazoles were obtained in good to excellent yields.

Synthesis and evaluation of in vivo anticonvulsant activity of 2,5-disubstituted-1,3,4-oxadiazole derivatives

A series of new 2,5-disubstituted-1,3,4-oxadiazole derivatives 8(a-o) was synthesized by the reaction of 1-(5-phenyl-1,3,4-oxadiazol-2-yl)piperazine with various sulfonyl chlorides. The synthesized compounds were characterized by elemental analyses,

A new entry of amination reagents for heteroaromatic C-H bonds: Copper-catalyzed direct amination of azoles with chloroamines at room temperature

Chloroamine serves as an efficient amination reagent to the heteroaromatic C-H bond of azole under copper catalysis even at room temperature. This catalysis enables a rapid and concise construction of aminoazoles of great interest in biological and medicinal chemistry.