122590-82-3

Basic information

• Product Name: Benzoic acid, 2,3,5,6-tetrafluoro-4-[(phenylmethyl)amino]-, methyl ester
• CAS NO: 122590-82-3
• Molecular Formula: C15H11F4NO2
• Molecular Weight: 313.251
• Mol File: 122590-82-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2,3,5,6-tetrafluoro-4-[(phenylmethyl)amino]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2,3,5,6-tetrafluoro-4-[(phenylmethyl)amino]-, methyl ester(122590-82-3)
• EPA Substance Registry System: Benzoic acid, 2,3,5,6-tetrafluoro-4-[(phenylmethyl)amino]-, methyl ester(122590-82-3)

Safety Data

• Hazardous Substances Data: 122590-82-3(Hazardous Substances Data)

Upstream product

• 122590-75-4 methyl 4-azidotetrafluorobenzoate 
• 602-94-8 Pentafluorobenzoic acid 
• 36629-42-2 methyl pentafluorobenzoate 
• 108-88-3 toluene 
• 100-46-9 benzylamine 
• 715-37-7 methyl 4-amino-2,3,5,6-tetrafluorobenzoate 
• 100-52-7 benzaldehyde 

Downstream Products

• 651734-51-9 methyl 4-(benzylamino)-3,5-difluoro-2,6-dimethoxybenzoate 
• 651734-52-0 4-(benzylamino)-3,5-difluoro-2,6-dimethoxybenzoic acid 
• 651734-54-2 2,6-difluoro-3,5-dimethoxybenzeneamine 
• 1513857-77-6 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3’,2’:5,6]pyrido[4,3-d]pyrimidin-2-one 

Relevant articles and documents

DERIVATIVES OF AN FGFR INHIBITOR

The present disclosure relates to derivatives (e.g., hydroxyl, keto, glucuronide, sulfonic acid, and deuterated) of a Fibroblast Growth Factor Receptors (FGFR) inhibitor, including methods of preparation thereof, and intermediates in the preparation thereof, which are useful in the treatment of FGFR mediated disease such as cancer.

USE OF KINASE INHIBITORS TO PROMOTE NEOCHONDROGENESIS

This invention provides methods for utilizing compounds that inhibit cyclin-dependent kinase and tyrosine kinase enzymes in the promotion of neochondrogenesis and the enhancement, protection and repair of cartilage. In certain embodiments the invention relates to methods of using compounds of formula (I): and pharmaceutically acceptable salts thereof, to promote neochondrogenesis, wherein, R1,R2, R3, R4, R5, R6, A, B, D, and E have any of the values defined therefor in the specification.

Descriptive Photochemistry of Polyfluorinated Azide Derivatives of Methyl Benzoate

The photochemistry of several polyfluorinated azide derivatives of methyl benzoate have been studied in a variety of solvents.We have photolyzed methyl 3-azido-6-fluorobenzoate, methyl 3-azido-4-fluorobenzoate, methyl 4-azido-2-fluorobenzoate, methyl 3-azido-2,4-difluorobenzoate, methyl 3-azido-2,6-difluorobenzoate, methyl 3-azido-2,4,6-trifluorobenzoate, and methyl 4-azido-2,3,5,6-tetrafluorobenzoate in toluene, cyclopentane, tetramethylethylene, diethylamine, dimethyl sulfide, dimethyl disulfide, and methanol in an attempt to capture the photogenerated reactive intermediates.Adducts were not formed in cyclopentane, dimethyl disulfide, and methanol solvents.Adducts were formed, however, but in modest yields, in the other solvents.In general the yield of adducts increases with the number of fluorine substituents present, and ortho and para fluorine substituents relative to the azide group are more effective in enhancing the yield of adducts relative to meta fluorine substitution.