1226775-22-9

Basic information

• Product Name: C₁₇H₁₆BrN₃S
• Synonyms: C₁₇H₁₆BrN₃S
• CAS NO: 1226775-22-9
• Molecular Weight: 374.304
• Mol File: 1226775-22-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₆BrN₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₆BrN₃S(1226775-22-9)
• EPA Substance Registry System: C₁₇H₁₆BrN₃S(1226775-22-9)

Safety Data

• Hazardous Substances Data: 1226775-22-9(Hazardous Substances Data)

Upstream product

• 99-90-1 para-bromoacetophenone 
• 104-87-0 4-methyl-benzaldehyde 
• 22946-44-7 1-(4-bromophenyl)-3-p-tolylprop-2-en-1-one 
• 79-19-6 thiosemicarbazide 

Downstream Products

• 1234016-38-6 C₂₅H₂₀BrN₃S 
• 1366267-89-1 C₁₉H₁₆BrN₃OS 

Relevant articles and documents

Design, synthesis and biological evaluation of pyrazolyl-thiazolinone derivatives as potential EGFR and HER-2 kinase inhibitors

A series of pyrazolyl-thiazolinone derivatives (E1-E36) have been designed and synthesized and their biological activities were also evaluated as potential EGFR and HER-2 kinase inhibitors. Thirty-four of the 36 compounds were reported for the first time. Among them, compound 2-(5-(4-bromophenyl)-3-p-tolyl-4,5- dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one (E28) displayed the most potent inhibitory activity (IC50 = 0.24 μM for EGFR and IC50 = 1.07 μM for HER-2). Antiproliferative assay results indicated that compound E28 owned high antiproliferative activity against MCF-7, B16-F10 and HCT-116 in vitro, with IC50 value of 0.30, 0.54, and 0.70 μM, respectively. Docking simulation was further performed to position compound E28 into the EGFR active site to determine the probable binding model. Based on the preliminary results, compound E28 with potent inhibitory activity in tumor growth would be a potential anticancer agent.