22946-44-7

Basic information

• Product Name: (2E)-1-(4-bromophenyl)-3-(4-methylphenyl)prop-2-en-1-one
• Synonyms: 2-propen-1-one, 1-(4-bromophenyl)-3-(4-methylphenyl)-, (2E)-
• CAS NO: 22946-44-7
• Molecular Formula: C₁₆H₁₃BrO
• Molecular Weight: 301.1778
• Mol File: 22946-44-7.mol
• Article Data: 29

Chemical Properties

• Boiling Point: 416.4°C at 760 mmHg
• Flash Point: 70°C
• Density: 1.354g/cm³
• Vapor Pressure: 3.82E-07mmHg at 25°C
• Refractive Index: 1.635
• CAS DataBase Reference: (2E)-1-(4-bromophenyl)-3-(4-methylphenyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-1-(4-bromophenyl)-3-(4-methylphenyl)prop-2-en-1-one(22946-44-7)
• EPA Substance Registry System: (2E)-1-(4-bromophenyl)-3-(4-methylphenyl)prop-2-en-1-one(22946-44-7)

Safety Data

• Hazardous Substances Data: 22946-44-7(Hazardous Substances Data)

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 766-97-2 4-n-methylphenylacetylene 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 7099-87-8 4-bromophenylglyoxylic acid 
• 104-87-0 4-methyl-benzaldehyde 
• 99-90-1 para-bromoacetophenone 
• 122-00-9 para-methylacetophenone 
• 589-18-4 4-Methylbenzyl alcohol 
• 5391-88-8 1-(4-bromophenyl)ethanol 

Downstream Products

• 1251194-84-9 C₂₄H₂₀BrNO 
• 155269-24-2 (2E)-1-(4-hydroxyphenyl)-3-(4-methylphenyl)prop-2-en-1-one 

Relevant articles and documents

1-(4-Bromophenyl)-3-(4-methylphenyl)prop-2-en-1-one

The characteristic features of crystal structure of 1-(4-bromphenyl)-3-(4-methylphenyl)prop-2-en-1-one, was analyzed. It was observed that phenone O atom deviates from least-squares plane of molecule by 0.300 A. The molecules pairs along [001] were hydrog

Highly stereoselective formation of 1,3-dioxolanes by photocatalytic ring opening reacrions of α-epoxyketones in acetone solution using 1-benzyl-2,4,6-triphenylpyridinium tetrafluoroborate (NBTPT)

Highly stereoselective formation of 1,3-dioxolanes has been observed on photoinduced electron transfer ring opening of α-epoxyketones by 1-benzyl-2,4,6-triphenylpyridinium tetrafluoroborate (NBTPT) in acetone solution. The presence of various substituents on the donor molecule has not affected the rate of the ring opening and also stereoselectivity of the reaction too much. Stepwise addition of the photocatalyst leads to decreasing of irradiation time and increasing of the yield of products. Photoinduced electron transfer deoxygenation and isomerization of some α-epoxyketones has also been observed. Cyclic voltammetric study of the photocatalyst shows a greater tendency of NBTPT for accepting an electron in the excited state.{A figure is presented}.

Transition metal-free domino aryl-aryl coupling/phospha-Michael addition of diarylphosphinite to α,β-unsaturated ketones triggered by alkaline hydrolysis of (4-(2-alkenoyl)phenyl)triarylphosphonium salts

Alkaline hydrolysis of a variety of (4-(2-alkenoyl)phenyl)triarylphosphonium bromides is reported. This hydrolysis triggers coupling of 4-(2-alkenoyl)phenyl with one aryl via phosphorus(V). Both diarylphosphinite and an α,β-unsaturated ketone are in situ generated and then undergo phospha-Michael addition to provide β-diarylphosphoryl ketones bearing a biaryl moiety in 27–70% yields in the absence of a transition metal.

Lewis acid catalyst system for Claisen-Schmidt reaction under solvent free condition

Ca(OTf)2 in combination with NBu4.BF4 was established to function as an efficient catalyst system for one-pot Claisen-Schmidt condensation under neat conditions. Substituted acetophenones and benzaldehydes were coupled in situ to afford their corresponding chalcones in excellent yields. The method, with a broad range of substrate tolerance and mild operational conditions can produce assorted chalcone derivatives in moderate to high yields from easily accessible starting materials.