22946-44-7

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 99-90-1 para-bromoacetophenone 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 7099-87-8 4-bromophenylglyoxylic acid 
• 1122-91-4 4-bromo-benzaldehyde 
• 766-97-2 4-n-methylphenylacetylene 
• 122-00-9 para-methylacetophenone 
• 589-18-4 4-Methylbenzyl alcohol 
• 5391-88-8 1-(4-bromophenyl)ethanol 

Downstream Products

• 115665-34-4 (4S,5R)-5-(4-Bromo-benzoyl)-1-(4-bromo-phenyl)-4-(4-methoxy-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester 
• 127612-47-9 2-(4-bromobenzoyl)-1-(4-bromophenyl)-4-carboethoxy-4-cyano-3,5-di-(4-tolyl) cyclohexanol 
• 127394-68-7 6-(4-Bromo-phenyl)-2-ethoxy-4-p-tolyl-nicotinonitrile 
• 51477-14-6 (4-bromophenyl)-3-(p-tolyl)oxiran-2-yl-methanone 
• 1251194-84-9 C₂₄H₂₀BrNO 
• 155269-24-2 (2E)-1-(4-hydroxyphenyl)-3-(4-methylphenyl)prop-2-en-1-one 

Relevant academic research and scientific papers

1-(4-Bromophenyl)-3-(4-methylphenyl)prop-2-en-1-one

The characteristic features of crystal structure of 1-(4-bromphenyl)-3-(4-methylphenyl)prop-2-en-1-one, was analyzed. It was observed that phenone O atom deviates from least-squares plane of molecule by 0.300 A. The molecules pairs along [001] were hydrog

Oxidative Cyclization of Chalcones in the Presence of Sulfamic Acid as Catalyst. Synthesis, Biological Activity, and Thermal Properties of 1,3,5-Trisubstituted Pyrazoles

Abstract: 1-Aroyl-3,5-diaryl-1H-pyrazoles weresynthesized by oxidative cyclization of chalcones with benzohydrazide and4-nitrobenzohydrazide using sulfamic acid as a catalyst. The correspondingchalcones were prepared by condensation of aromatic aldehydes with acetophenonesin PEG-400 in the presence of potassium hydroxide. Some representative featuresof the proposed procedure include exceptional regioselectivity, comparativelyshort reaction time, operational simplicity, and no need of external oxidant.The synthesized pyrazole derivatives were screened as antibacterial agentsagainst Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Salmonellatyphi by the agar well diffusion method. Attempts were made tocompute specific heat capacity of the synthesized pyrazole derivatives as afunction of temperature using TGA–DSC in order to avail thermodynamic databasefor these biologically relevant heterocycles.

Highly stereoselective formation of 1,3-dioxolanes by photocatalytic ring opening reacrions of α-epoxyketones in acetone solution using 1-benzyl-2,4,6-triphenylpyridinium tetrafluoroborate (NBTPT)

Highly stereoselective formation of 1,3-dioxolanes has been observed on photoinduced electron transfer ring opening of α-epoxyketones by 1-benzyl-2,4,6-triphenylpyridinium tetrafluoroborate (NBTPT) in acetone solution. The presence of various substituents on the donor molecule has not affected the rate of the ring opening and also stereoselectivity of the reaction too much. Stepwise addition of the photocatalyst leads to decreasing of irradiation time and increasing of the yield of products. Photoinduced electron transfer deoxygenation and isomerization of some α-epoxyketones has also been observed. Cyclic voltammetric study of the photocatalyst shows a greater tendency of NBTPT for accepting an electron in the excited state.{A figure is presented}.

Fluorine as a robust balancer for tuning the reactivity of topo-photoreactions of chalcones and the photomechanical effects of molecular crystals

Fluorine-free chalcones and chalcones bearing different numbers of fluorine atoms have been synthesized. It is found that fluorine can tune the reactivity of photo-induced [2 + 2] cycloaddition reactions in crystals. The higher the number of fluorine atom

Efficient base-free asymmetric one-pot synthesis of spiro[indoline-3,3′-pyrrolizin]-2-one derivatives catalyzed by chiral organocatalyst

A 1,3-dipolar cycloaddition reaction has been performed under organocatalytic conditions with high enantioselectivity by the utilization of bipyridine-based chiral quaternary ammonium bromide as an organocatalyst. Here, the reaction of 1,3-dipolar cycloaddition of azomethine ylide generated in situ from the decarboxylative condensation of α-amino acids and non-enolizable 1,2-diketones to the above dipolarophiles takes place.

Transition metal-free domino aryl-aryl coupling/phospha-Michael addition of diarylphosphinite to α,β-unsaturated ketones triggered by alkaline hydrolysis of (4-(2-alkenoyl)phenyl)triarylphosphonium salts

Alkaline hydrolysis of a variety of (4-(2-alkenoyl)phenyl)triarylphosphonium bromides is reported. This hydrolysis triggers coupling of 4-(2-alkenoyl)phenyl with one aryl via phosphorus(V). Both diarylphosphinite and an α,β-unsaturated ketone are in situ generated and then undergo phospha-Michael addition to provide β-diarylphosphoryl ketones bearing a biaryl moiety in 27–70% yields in the absence of a transition metal.

Synthesis of 3-fluoro-2,5-disubstituted furans through ring expansion ofgem-difluorocyclopropyl ketones

The synthesis of 3-fluoro-2,5-disubstituted furans fromgem-difluorocyclopropyl ketones was accomplished using trifluoromethanesulfonic acid (CF3SO3H) through ring expansion owing to the activation of the carbonyl group in the starting material. The present synthesis of 3-fluorofurans tolerates substrates designed for products with aromatic substituents at the C-2 and C-5 positions.

Antiproliferative effects of chalcones on T cell acute lymphoblastic leukemia-derived cells: Role of PKCβ

In this study, a series of 20 chalcone derivatives was synthesized, and their antiproliferative activity was tested against the human T cell acute lymphoblastic leukemia-derived cell line, CCRF-CEM. On the basis of the structural features of the most active compounds, a new library of chalcone derivatives, according to the structure–activity relationship design, was synthesized, and their antiproliferative activity was tested against the same cancer cell line. Furthermore, four of these derivatives (compounds 3, 4, 8, 28), based on lower IC50 values (between 6.1 and 8.9 μM), were selected for further investigation regarding the modulation of the protein expression of RACK1 (receptor for activated C kinase), protein kinase C (PKC)α and PKCβ, and their action on the cell cycle level. The cell cycle analysis indicated a block in the G0/G1 phase for all four compounds, with a statistically significant decrease in the percentage of cells in the S phase, with no indication of apoptosis (sub-G0/G1 phase). Compounds 4 and 8 showed a statistically significant reduction in the expression of PKCα and an increase in PKCβ, which together with the demonstration of an antiproliferative role of PKCβ, as assessed by treating cells with a selective PKCβ activator, indicated that the observed antiproliferative effect is likely to be mediated through PKCβ induction.

Lewis acid catalyst system for Claisen-Schmidt reaction under solvent free condition

Ca(OTf)2 in combination with NBu4.BF4 was established to function as an efficient catalyst system for one-pot Claisen-Schmidt condensation under neat conditions. Substituted acetophenones and benzaldehydes were coupled in situ to afford their corresponding chalcones in excellent yields. The method, with a broad range of substrate tolerance and mild operational conditions can produce assorted chalcone derivatives in moderate to high yields from easily accessible starting materials.

Fabrication of Copper-based Silica-coated Magnetic Nanocatalyst for Efficient One-pot Synthesis of Chalcones via A3 Coupling of Aldehydes-Alkynes-Amines

In the present work, we have synthesized bioactive and pharmacologically important chalcone motifs by employing green and efficient silica-coated magnetically separable catalyst, Cu@DBM@ASMNPs. The highly proficient nanocatalyst proves its invincibility f