1234016-38-6

Basic information

• Product Name: C₂₅H₂₀BrN₃S
• CAS NO: 1234016-38-6
• Molecular Weight: 474.424
• Mol File: 1234016-38-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₂₀BrN₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₂₀BrN₃S(1234016-38-6)
• EPA Substance Registry System: C₂₅H₂₀BrN₃S(1234016-38-6)

Safety Data

• Hazardous Substances Data: 1234016-38-6(Hazardous Substances Data)

Upstream product

• 99-90-1 para-bromoacetophenone 
• 104-87-0 4-methyl-benzaldehyde 
• 22946-44-7 1-(4-bromophenyl)-3-p-tolylprop-2-en-1-one 
• 1226775-22-9 C₁₇H₁₆BrN₃S 
• 70-11-1 α-bromoacetophenone 

Relevant articles and documents

Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives as EGFR TK inhibitors and potential anticancer agents

Fourty-two thiazolyl-pyrazoline derivatives were synthesized to screen for their EGFR kinase inhibitory activity. Compound 4-(4-chlorophenyl)-2-(3-(3,4- dimethylphenyl)-5-p-tolyl-4,5-dihydro-1H-pyrazol-1-yl)thiazole (11) displayed the most potent EGFR TK inhibitory activity with IC50 of 0.06 μM, which was comparable to the positive control. Molecular docking results indicated that compound 11 was nicely bound to the EGFR kinase. Compound 11 also showed significant antiproliferative activity against MCF-7 with IC 50 of 0.07 μM, which would be a potential anticancer agent.