122682-77-3

Upstream product

• 36050-78-9 Bis(trimethylsilyl)methylidene triphenylphosphorane 
• 118-41-2 Eudesmic acid 
• 51490-01-8 1-(3,4,5-trimethoxyphenyl)-2-bromoethanone 
• 603-35-0 triphenylphosphine 
• 1136-86-3 methyl (3,4,5-trimethoxyphenyl) ketone 

Downstream Products

• 1301603-38-2 (2E)-3-(7-chloro-3-methyl-1,4-dioxoquinoxalin-2-yl)-1-(3,4,5-trimethoxyphenyl)propenone 
• 1301603-39-3 (2E)-3-(3,7-dimethyl-1,4-dioxoquinoxalin-2-yl)-1-(3,4,5-trimethoxyphenyl)propenone 
• 1301603-40-6 (2E)-1-(3,4,5-trimethoxyphenyl)-3-(3,6,7-trimethyl-1,4-dioxoquinoxalin-2-yl)-propenone 
• 1301603-36-0 (2E)-3-(7-fluoro-3-methyl-1,4-dioxoquinoxalin-2-yl)-1-(3,4,5-trimethoxyphenyl)propenone 
• 1301603-35-9 (2E)-3-(3-methyl-1,4-dioxoquinoxalin-2-yl)-1-(3,4,5-trimethoxyphenyl)propenone 
• 1301603-37-1 (2E)-3-(7-methoxy-3-methyl-1,4-dioxoquinoxalin-2-yl)-1-(3,4,5-trimethoxyphenyl)propenone 

Relevant academic research and scientific papers

Fe-Catalyzed Cycloisomerization of Aryl Allenyl Ketones: Access to 3-Arylidene-indan-1-ones

A cycloisomerization of aryl allenyl ketones to 3-arylidene-indan-1-ones using a cationic Fe-complex as a catalyst is reported. The catalyst opens a synthetically interesting reaction pathway to this surprisingly underrepresented class of indanones that are not accessible using alternative catalytic systems.

Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents

We report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds 1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity

Stereoselective Synthesis of Lignans of Three Structural Types from a Common Intermediate, Enantioselective Synthesis of (+)-Yangambin

Enantioselective total synthesis of (+)-yangambin was achieved. The key transformation is one-pot conjugate addition/aldol reaction that involves an enantioenriched benzyl tert-butyl sulfoxide, an enone, and gaseous formaldehyde to construct the bis(pheny

Synthesis and Biological Evaluation of New Quinoxaline Derivatives as Antioxidant and Anti-Inflammatory Agents

We report the synthesis, anti-inflammatory, and antioxidant activities of novel quinoxaline and quinoxaline 1,4-di-N-oxide derivatives. Microwave-assisted methods have been used to optimize reaction times and to improve yields. The tested compounds presented important scavenging activities and promising in vitro inhibition of soybean lipoxygenase (LOX). Two of the best LOX inhibitors (compounds 7b and 8f) were evaluated as invivo anti-inflammatory agents using the carrageenin-induced edema model. One of them (compound 7b) showed important in vivo anti-inflammatory effect (41%) similar to that of indomethacin (47%) used as the reference drug. Synthesis and Biological Evaluation of New Quinoxaline Derivatives as Antioxidant and Anti-Inflammatory Agents Asuncion Burguete, Eleni Pontiki, Dimitra Hadjipavlou-Litina*, Saioa Ancizu, Raquel Villar, Beatriz Solano, Elsa Moreno, Enrique Torres, Silvia Perez, Ignacio Aldana and Antonio Monge The synthesis, anti-inflammatory and antioxidant activities of new quinoxaline derivatives are reported. The new compounds exhibit important scavenging activities and promising values of in vitro inhibition of soybean LOX, One of them shows strong in vivo anti-inflammatory effect similar to that of indomethacin used as the reference drug.